The findings suggest that altered Ca2+ current, but not altered Na(+)-Ca2+ exchange current or altered transient outward current, significantly prolongs action potential duration in diabetic rat ventricular muscles.

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Summary Effect of lysophosphatidylcholine (LPC) on the inward rectifier K channel of the isolated guinea pig ventricular cell was studied using patch clamp technique. In that LPC (100 ,uM) decreased the magnitude of the single channel conductance from 48±5 pS (mean and S.D., n=5) to 12±9 pS (n=8), this event may be the prime factor related to the alleged LPC-induced depolarization of cardiac tissues.