The aim of this article is to draw attention of gastroenterologists, surgeons and primary care physicians to the features of the course of pancreatitis complications, which tend to have an acute course and are a complex process that causes medical errors and life tragedies. The importance of complications of pancreatitis such as cysts, pseudocysts, fistulas, cholestatic syndrome, portal hypertension syndrome, bleeding from varicose veins of the esophagus, stomach and erosive-ulcerative secondary gastroduodenal processes is emphasized. Attention is focused on the mechanisms of development of these complications, features of the clinical course, management tactics of such patients, depending on the location of the complications, which is important for the treatment strategy (conservative or surgical). The peculiarities of the clinical picture of the syndrome of compression of neighboring organs, thrombosis of the hepatic and splenic veins, biliodigestive bleeding, including hemobilia, bleeding from the large and small duodenal papilla, are directly related to the analytical approach regarding the diagnosis of these complications. Angiographic techniques are considered to be the most effective diagnostic techniques, which include celiacography, upper mesentericography, percutaneous and transhepatic portography. It is indicated that on their basis, techniques for stopping bleeding have been developed, namely endovascular catheter hemostasis.
INTRODUCTION: The effect of hormonal status on the functional state of the liver and endocrine disfunction caused by liver diseases are beyond doubt for most authors. OBJECTIVES: The aim was to assess thyroid homeostasis in patients with chronic hepatitis and analyze the association between serum thyroid parameters and A/C polymorphism of the deiodinase type 1 (DIO1) gene. METHODS: The study was conducted on 50 patients with chronic hepatitis and 20 healthy controls. The serum free thyroxine (fT4), free triiodothyronine (fT3) and thyroid stimulating hormone (TSH) were measured and fT3/fT4, fT4/fT3, TSH/fT3, TSH/fT4 ratio, thyroid index and total thyroid index were calculated. The alleles of the polymorphic A/C sites in the DIO1 gene were studied. RESULT: The level of fT3 was reduced and fT4 level was increased in patients with chronic hepatitis. The fT3/fT4 ratio decreased below the reference range and fT4/fT3 ratio increased by 24,1%. Elevation of the TSH level and TSH/fT3 ratio were determined. The titres of tyroglobulin autoantibodies and antithyroid peroxidase antibodies significantly exceeded the control values. It has been established that the carriage of the C-allele DIO1 was associated with an increasing fТ3 level and fТ3/fТ4 ratio, and a decreasing fТ4/fТ3 ratio and fТ4 level, while the presence of А-allele resulted in a decrease in the fТ3/fТ4 ratio and serum fТ3 with the increase in Т4 level in patients with chronic hepatitis.CONCLUSIONS: Chronic hepatitis is accompanied by the development of non-thyroidal illness syndrome. Pathologycal changes in thyroid metabolism are associated with A/C polymorphism of the DIO1 gene. UDC Classification: 616.3; DOI: http://dx.
Introduction: This paper discusses the possibility of polarization microscopic tomography of polycrystalline structure of vitreous body (VB) for use in forensics and in determining the time since death (TSD). Objectives: The purpose of this study was to develop a new set of forensic criteria to enhance the functionality of the high-precision definition of TSD over a long period of time according to polarization microscopic tomography of the polycrystalline structure of the VB of the human eye by statistical and wavelet analysis. Results: We obtained the numerical values of the change in the magnitude of the statistical moments of the 1-4 orders, which characterize the coordinate distributions of the magnitude of the linear birefringence (LB) of the polycrystalline component of the VB by the magnitude of the TSD. The results from our research illustrate the differences between the optical anisotropy of fibrillar collagen networks of VB layers with different TSD. The sensitivity range (36 hours) and accuracy (15 minutes) of the method of polarization tomography of the LB distributions of the polycrystalline component of the VB layers in the determined TSD were established. Conclusion: These results confirm the experimental processes outlined accurately determine the time of death. In turn, will provide scientific evidence, specifications thereof, and objective expert opinion.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.