Gastric cancer is the third leading cause of cancer death with 5-year survival rate of about 30-35%. Since early detection is associated with decreased mortality, identification of novel biomarkers for early diagnosis and proper management of patients with the best response to therapy is urgently needed. Long noncoding RNAs (lncRNAs) due to their high specificity, easy accessibility in a noninvasive manner, as well as their aberrant expression under different pathological and physiological conditions, have received a great attention as potential diagnostic, prognostic, or predictive biomarkers. They may also serve as targets for treating gastric cancer. In this review, we highlighted the role of lncRNAs as tumor suppressors or oncogenes that make them potential biomarkers for the diagnosis and prognosis of gastric cancer.Relatively, lncRNAs such as H19, HOTAIR, UCA1, PVT1, tissue differentiation-inducing nonprotein coding, and LINC00152 could be potential diagnostic and prognostic markers in patients with gastric cancer. Also, the impact of lncRNAs such as ecCEBPA, MLK7-AS1, TUG1, HOXA11-AS, GAPLINC, LEIGC, multidrug resistance-related and upregulated lncRNA, PVT1 on gastric cancer epigenetic and drug resistance as well as their potential as therapeutic targets for personalized medicine was discussed.

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Periorbital hyperpigmentation (also recognized as periorbital melanosis, dark eye circles, and infraorbital darkness) is public cosmetic skin disorder with relative darkness of the periorbital. This condition is affected both sexes, they get worse by aging so it makes people look tired and older so it has a negative effect on the quality of life, particularly in women. 1 Many exogenous and endogenous reasons are overly involved in the pathogenesis of periorbital dark circles, containing genetics or heredity, facial structure, hyperpigmentation secondary to allergic and atopic contact dermatitis, troubled sleeping, smoking, alcohol drinking, and sun exposure can play a role in the development of these dark circles. 2 Several treatments are recommended for periorbital hyperpigmentation. However, there are

Background The search of beauty and youth has received a lot of attention which is proved by increasing cosmetic techniques. The people prefer non‐surgical and invasive method for reduction and wrinkles treatment. Methods In this study, we used Endolift laser for forehead wrinkles and frown line treatment to evaluate the clinical safety and effectiveness of this technique for reduction of forehead wrinkles and frown line. A total of 9 patients with forehead wrinkles and frown line were included in the current study. The results were investigated using biometric evaluation. Also, assessment was performed clinically and photographically, and physician's assessment and patient satisfaction responses were recorded. Results According to the biometric results, the skin thickness and elasticity significantly increase after Endolift laser treatment. According to the physician's assessment, 90% of patients displayed very much improvement after Endolift laser treatment, and according to the patient assessment, 91% of patients reported positive satisfaction response. Conclusion Treatment with Endolift laser is safe and an effective method for decrease of forehead wrinkles and frown line treatment. It offers as a non‐invasive alternative technique in compared to other invasive procedures for forehead wrinkles and frown line treatment.

Drooping of the upper eyelid and eyebrow (ptosis) is common among people and cause the patients dissatisfaction. Various methods have been developed to treatment of the upper eyelid and eyebrow ptosis. However, the current methods focus on surgery to improve the disorder. But patients are worried about the risks of the procedure, and seeking for a non‐invasive alternative method. Therefore, non‐invasive methods with consistent efficient improvement are needed, especially for middle‐aged patients. This study was conducted of 9 patients who underwent the upper eyelid and eyebrow ptosis. Endolift laser method was used to treat the patients’ upper eyelid and eyebrow ptosis. The biometric assessment was used to evaluate the efficiency of the technique. Also the results were evaluated by 3 board‐certified dermatologists (blind). Additionally, patients’ satisfaction was evaluated at the end of the treatment. The biometric results showed that Endolift laser can increase the thickness, density, and elasticity of the skin in the eyelid area. The patient's satisfaction results showed excellent improvement in the 90% of patients. The results by the dermatologist displayed improvement in about 90% of patient. Endolift laser has been proved efficient and consistent for upper eyelid and eyebrow ptosis rejuvenation and treatment.