Involvement of dopamine D1/D2 receptors on harmane-induced amnesia in the step-down passive avoidance test

Characteristics of Antiamnestic Effects of Blockade and Activation of Dopamine D1 Receptors after Stress Stimulation in Mice

“…Second, the antiamnestic effect of SCH23390 in mice with behavioral despair was more pronounced than in mice with unchanged baseline condition, since it was observed on day 1 of the testing and transition latencies during CPA testing were longer (134±14 sec in stressed mice and 78±22 sec in normal mice. Similar direction of antiamnestic effects of D1-receptor activation and blockade agree with published data [3,12,14,15].…”

“…Bearing in mind the importance of dopamine (DA) system in the regulation of the responses to stress stimulation used for the modeling of depressive behavior [1,5,9] and in the development of various amnesias [11,[13][14][15], it is interesting to study the role of D1-and D2-receptor functions in the control of the resistance to the amnestic agents. D1-and D2-receptors are known to play either complementary or opposite roles in antiamnestic effects of pharmacological DA-agents [3,12,14]. However, the effect of baseline functional state of the organism on the effi ciency of DA-agents is poorly studied.…”

Low and high doses of Norharmane respectively improve and impair learning and memory in streptozotocin-induced rat model of sporadic alzheimer’s disease

“…In agreement with these results, it has been shown that immediate intra peritoneal administration of HA (5 and 10 mg/kg) after training impaired learning and memory [49]. It has also been reported that administration of HA, to rat elicited visuomotor, spatial learning and memory deficiencies in a dose-dependent manner [50]. Similar results were obtained when β-carbolines, such as HA and NO were administered [51,52].…”

Original article Involvement of D 2 /D 2 dopamine antagonists upon open-arms exploratory behaviours induced by intra-nucleus accumbens shell administration of N-methyl-D-aspartate

“…Based on some other reports, the intra-dorsal hippocampal [62] and peripheral [2,15] administration of the antagonists impair the one-trial passive avoidance and spatial or non-spatial memories in mice, respectively. However, other investigations indicate that pre-test single administration of SCH 23390 or sulpiride causes no significant change in the step-down latency [56]. One study demonstrated that inhibition of the dopamine exocytosis from pre-synaptic neuron via Ca 2+ -channel blockade by SKF96365 decreases anxiolytic-like behaviours induced by sulpiride in the NAc shell region indicating the involvement of the pre-synaptic dopamine D 2 receptors in sulpiride induced anxiolytic-like behaviours [3].…”