This study determined the effect of cooperative teaching strategy and instructional material utilization on Mathematics learning achievement of senior secondary school students in Fika LGA, Yobe State, Nigeria. Two (2) objectives were stated and two (2) null hypotheses were tested. Quasi-experimental design was adopted. The population comprised of one hundred and forty (140) students selected from the four senior secondary schools in the study area. Thirty five (35) students were purposively selected from each of the four senior secondary schools. Achievement Test in Mathematics was adapted for the study. Three stages were used in collecting the data: pre-treatment, treatment and post-treatment phases. Independent sample t-test was used to analyze the two (2) null hypotheses. The results were considered at P< 0.05 level. The finding of the study showed that cooperative teaching strategy had significant effect on mathematics learning achievement of senior secondary school students. It is further discovered that instructional material utilization had significant effect on mathematics learning achievement of the students. It is recommended among others that effective use of cooperative teaching strategy and instructional material utilization in teaching mathematics in schools should be used by teachers to enhance student learning achievement in mathematics.