Intrauterine insemination (IUI) is the first-line treatment for many patients seeking assisted reproduction. IUI is of greater accessibility, and of lesser invasiveness and risk than in vitro fertilization. 1 Although many couples have the benefit of using a male partner's sperm for insemination, many others rely on donor sperm, such as couples with severe male factor infertility, single women, and samesex female couples.It is a common view that IUI with donor sperm is associated with greater success than with partner sperm. There is research to support this-although the number of studies on this topic is surprisingly limited. Dong et al. 2 noted a clinical pregnancy rate of 10.8% among insemination with 'husband' sperm and a rate of 27.5% with donor sperm, among 6360 insemination cycles. Other authors note that "donor sperm is of higher quality", 3 and "quality of donor sperm is expected to be excellent, well above the semen quality of the 'general' population". 4
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