Outcomes of donor versus partner sperm in intrauterine insemination in women aged 38 years and older

Frank, Russell; Steiner, Naama; Shatti, Maryam Al; Ruiter-Ligeti, Jacob; Dahan, Michael H.

doi:10.1002/ijgo.13694

Cited by 2 publications

(1 citation statement)

References 12 publications

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“…Dong et al ( 31 ) studied artificial insemination cycles using partner and donor sperm and found that the clinical pregnancy rate of the donor sperm group was higher than that of the partner sperm group (27.5% vs. 10.8%). Frank et al ( 32 ) compared the clinical outcomes of women aged ≥38 years who underwent artificial insemination using partner sperm and donor sperm and found that the clinical pregnancy rate of the donor sperm group was higher than that of the partner sperm group. However, the difference between the groups was not significant (8% vs. 5.8%).…”

Section: Discussionmentioning

confidence: 99%

Effects of donor sperm on perinatal and neonatal outcomes resulting from in vitro fertilization-intracytoplasmic sperm injection and embryo transfer cycles: a retrospective cohort study

Gao¹,

Sun²,

Xie³

et al. 2022

Ann Transl Med

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Background The impact of donor sperm on pregnancy outcomes is controversial. The aim of this study was to investigate whether donor sperm in in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) treatment could reduce the rate of live births or increase the incidence of adverse pregnancy outcomes and birth defects in neonates. Methods This single-centre, retrospective cohort study included 1,559 patients with infertility who received donor sperm at our hospital from 2015 to 2019. All the patients received fresh embryos and underwent first-cycle transfer. After propensity score matching, 4,677 controls who received their partners’ sperm were matched at 1:3. Clinical pregnancy, perinatal, and neonatal outcomes were compared between the donor sperm and partner sperm groups. Results The embryo development was better in the donor sperm group than in the partner sperm group. The high-quality embryo and available embryo rates were significantly higher in the donor sperm group (P<0.05 for both groups). The rate of high-quality embryos transferred from the donor sperm group was higher than that from the partner sperm group (P<0.05). The clinical pregnancy (62.99% vs. 59.65%; P=0.02) and live birth (54.65% vs. 51.59%; P=0.036) rates were higher in the donor sperm group. After adjusting for confounding factors, no significant difference in live birth rates was observed between the two groups (adjusted P=0.057). The low birthweight (18.21% vs. 21.39%; P=0.023) and small for gestational age (SGA) (7.60% vs. 11.97%; P<0.001) rates were lower in the donor sperm group. To exclude the effect of multiple pregnancies, we evaluated neonatal outcomes of singleton pregnancies. No significant differences were noted in preterm and very preterm birth, SGA, mean birthweight, high birthweight, and low birth weight (LBW) and very low birth weight (VLBW) rates (P>0.05 for both groups). Further, no significant between group differences were observed in the ectopic pregnancy rate, early and late spontaneous abortion rates, gestational age, rate of large for gestational age (LGA), and neonatal defects. Conclusions Compared with partner sperm, donor sperm did not reduce live birth rate and did not increase neonatal LBW or low birth defects.

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Section: Discussionmentioning

confidence: 99%

Effects of donor sperm on perinatal and neonatal outcomes resulting from in vitro fertilization-intracytoplasmic sperm injection and embryo transfer cycles: a retrospective cohort study

Gao¹,

Sun²,

Xie³

et al. 2022

Ann Transl Med

View full text Add to dashboard Cite

show abstract

Cumulative live birth rates following intrauterine insemination using donor and husband sperm in different age groups: A cohort study of 10 415 insemination cycles

Zhang,

Cai,

Xie

et al. 2024

Intl J Gynecology & Obste

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ObjectivesTo assess the age‐specific cumulative live birth rates (CLBRs) in intrauterine insemination (IUI) cycles using either donor or husband sperm, and to investigate the impact of sperm sources on IUI success among women within the same age group.MethodsThis retrospective cohort study comprised women who underwent IUI with donor sperm (IUI‐D) or husband sperm (IUI‐H) from 2017 to 2021. The women were stratified based on their age at the initiation of insemination into four categories: <35, 35–37, 38–39 and ≥40 years.ResultsA total of 5253 women undergoing 10 415 insemination cycles (3354 with IUI‐D and 7061 with IUI‐H) were included. The CLBRs decreased significantly with increasing maternal age within donor and husband insemination groups (P < 0.001). In the IUI‐D group, the crude CLBRs were 61.50% in women aged <35, 48.91% in 35–37, 24.14% in 38–39 and 11.76% in the ≥40‐year age category, respectively. The corresponding rates in the IUI‐H group were 27.62%, 22.96%, 13.73% and 6.90%, respectively. Within the <35 and 35–37‐year age categories, the CLBRs were significantly higher following IUI‐D cycles compared to IUI‐H cycles, with hazard ratios (HR) of 1.85 (1.68–2.04) and 1.69 (1.16–2.47), respectively. However, within the 38–39 and ≥40‐year age categories, both IUI‐D and IUI‐H resulted in comparable low CLBRs, with HRs of 1.91 (0.77–4.76) and 1.80 (0.33–9.86), respectively.ConclusionAdvanced maternal age affects the whole process of fertility. Therefore, it could be reasonable to limit the number of IUI performed in women aged 40 years and older, even in couple using donor sperm for reproduction.

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Outcomes of donor versus partner sperm in intrauterine insemination in women aged 38 years and older

Cited by 2 publications

References 12 publications

Effects of donor sperm on perinatal and neonatal outcomes resulting from in vitro fertilization-intracytoplasmic sperm injection and embryo transfer cycles: a retrospective cohort study

Effects of donor sperm on perinatal and neonatal outcomes resulting from in vitro fertilization-intracytoplasmic sperm injection and embryo transfer cycles: a retrospective cohort study

Cumulative live birth rates following intrauterine insemination using donor and husband sperm in different age groups: A cohort study of 10 415 insemination cycles

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