A new /M,3-D-glucan synthesis inhibitor, L-687,781 is produced by the cultivation of Dictyochaeta simplex ATCC20960. L-687,781 exhibits potent in vitro antifungal activity as well as anti-Pneumocystis activity in a rat model.

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Novel zaragozic acids, potent inhibitors of squalene synthase, have been isolated from a fermentation that produces zaragozic acid C (1). Zaragozic acid F (4) represents the first zaragozic acid possessing a non-aromatic alkyl side chain (at position 1).

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SUMMARYUtilizing sodium [1-14C]propionate as a precursor, [14C]FK-506. labeled at carbon atoms 10, 16, 18, 21a, 24, and 26, was produced by fermentative biosynthesis.Extractive isolation followed by chromatographic purification provided material of purity suitable for metabolism studies.