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This study examines religious faith as associated with adjustment to end-stage renal failure and its treatment regimen of maintenance hemodialysis. Both quantitative and qualitative data were collected initially and after a three-year interval in order to observe changes over time. The variable of the patient's perception of the import of religious faith was found to be positively related to interactional behavior and sick role behavior and to be inversely associated with alienation. Content analysis of qualitative responses for the item of perceived import of religious faith revealed a pattern of increasingly more positive patient attitudes occurring over time.