Thermoresponsive polymers have been attractively and scientifically significant in the recent years due to the utilization of various pharmaceutical and biomedical formulations. Poly(N-vinylcaprolactam) (PNVCL) is a temperature-responsive polymer, only second to poly(N-isopropylacrylamide) (PNIPAM), the most popular temperature-responsive polymer. PNVCL should be considered an important focus due to the phase transition temperature of such polymer that is close to the physiological temperature. PNVCL is a polymer which offers unrivaled qualities for different potential medical device applications. Specifically, it offers one kind of thermoresponsive abilities, which satisfies the material innovation imperatives required in focused drug delivery applications. PNVCL and PNIPAM polymers are well-studied thermoresponsive abilities since its lower critical solution temperature (LCST) is near the physiological temperature and has mostly been used in biomedical applications. Therefore, it can be investigated as a potential candidate for pharmaceutical utilization. This review highlights a comparison of PNVCL with PNIPAM regarding comparable characteristics which also delve into selected examples and the most recent published of applications based on PNVCL with a specific focus on drug delivery system. The consequence exhibits that the PNVCL will play a pivotal role in nanotechnology and the environment.

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Recently, common research on stimuli-responsive polymers comprising thermoresponsive polymers has been widely investigated. In this research study, the synthesis process parameters of poly(Nvinylcaprolactam) (PNVCL) a thermoresponsive polymer, has been engaged for optimization as an attempt. The response surface methodology (RSM), has been employed in the identification of the elevated factors affecting on PNVCL production conversion (%) yield. Four independent process variables including monomer concentration, initiator concentration, polymerization temperature and time were studied. Various polymerization combination factors consist of a set of experiment runs were discussed using the Box-Behnken approach in Minitab 16. The study efficiently established the procedure and recompenses of RSM, for the estimation of process response. The optimum value for the most significant (temperature and time) variables for maximum PNVCL conversion (%) yield were obtained to be ~80 °C and 92.5 min, respectively. Monomer and initiator concentrations were hardly effective on the (%) yield.

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A novel comparison study based on a radial basis function neural network (RBFNN) and Response Surface Methodology (RSM) is proposed to predict the conversion rate (yield) of the experimental data for PNVCL polymerization. A statistical and optimization model was performing to show the effect of each parameter and their interactions on the conversion rate. The influence of the time, polymerization temperature, initiator concentration and concentration of the monomer were studied. The results obtained in this study indicate that the RBFNN was an effective method for predicting the conversion rate. The time of the PNVCL polymerization as well as the concentration of the monomer show the maximum effect on the conversion rate. In addition, compared with the RSM method, the RBFNN showed better conversion rate comparing with the experimental data.

Poly(N-vinylcaprolactam) (PNVCL) offers superior characteristics as a thermoresponsive polymer for various potential applications. An attractive procedure, namely in-situ polymerization, was used to prepare NVCL/clay nanocomposite in different clay ratios. Organo-modified clay as C20 and B30 were employed in a range between 1–5% based on weight. Thermogravimetric analysis (TGA) and Fourier transform infrared spectroscopy (FTIR) were used to study thermal decomposition and to assess bond conversion during polymerization of the nanocomposite. This research was conducted to study PNVCL characteristics with the addition of clay as a nanocomposite. The stretch mode of the carboxylic group (C=O) and (C=C) was present in the band range about ~1635 cm–1 for the C20, but it was ranging between 1640 to 1664 cm–1 for the B30 of the nanocomposite. It was observed that the decomposition was different for each type of organoclay and the temperature peaked at 30 to 800 °C, to measure the degradation points at 5, 10, and 50%. Comparison results for FTIR and TGA showed that the best nanocomposite was found in the C20 (3%) case.