Conclusions: AZD4547 had an acceptable safety profile but minimal activity in this predominantly FGFR1/FGFR3amplified cohort. Evaluation of other targeted agents in Lung-MAP is ongoing.

This study investigated whether or not Ss manifested greater conscious concerns about death in direct proportion to their frequency of nightmares. On a 10-item Death Scale there was found a marked relationship between scores on the scale and nightmare frequency. There was also a suggestion that both nightmare behavior and/or attitudes toward death might be rooted in concrete experiences. The more frequent nightmare Ss had a history of greater frequency of deaths of relatives and close friends, especially when Ss were under 10 yr. of age.

When subjects (Ss) respond to personality questionnaires, it cannot be assumed that the test instructions serve as the only or even the major set followed by the Ss. Other self-imposed sets may bias test responses. Meehl and Hathaway (1946) and Cronbach (1946) have both cogently described how test taking attitudes intrude upon personality tests. More recently, Edwards (1957) has stressed the importance of social desirability (SD) stereotypes as a biasing factor. He seems to suggest that this particular response set is so pervasive that it impairs the validity of most standard personality inventories. For Edwards, the forced choice technique affords a possibility of minimizing the effects of SD. His own scale, the Edwards Personal Preference Schedule (EPPS), is constructed accordingly. The forced choice format calls for responses to pairs of statements; the pairs presumably have been equated for SD on the basis of prior ratings of the separate components of the pair.In an earlier study (Corah, Feldman, Cohen, Gruen, Meadow, & Ringwall, 1958) of part of the EPPS, it was found that for the majority of pairs 5s could readily choose one member of the pair as being more desirable. Further, there was a high correlation between SD ratings of the pairs and degree of endorsement of the items within the pairs. A replication of this study on the entire EPPS (Edwards, Wright, & Lunneborg, 1959) produced a somewhat lower degree of correlation between SD ratings and item endorsement. However, they found an average correlation of around .60 which is still substantial and considerably higher than the .40 correlation reported earlier by Edwards (1959) which was based upon responses to single items rather than pairs. We suggested

No abstract

Primary effusion lymphoma (PEL) is a common cancer in AIDS patients closely associated with Kaposi’s sarcoma-associated herpesvirus (KSHV). Previously, we showed that KSHV latency associated nuclear antigen (LANA) stabilizes intracellular activated Notch1 (ICN) involved in maintenance of the malignant phenotype of KSHV infected PEL cells in vitro. The γ-secretase inhibitor (GSI) which specifically blocks the production of ICN slows down the proliferation of the KSHV infected PEL cell lines BCBL1, BC3 as well as JSC1 in vitro. In this study, we extended these studies to explore the possibility that manipulation of the Notch signaling by GSI would prevent the growth of the PEL tumors in vivo. We observed that the onset of tumorigenesis of KSHV infected PELs was significantly delayed in GSI treated SCID mice harboring the PEL cell lines. We also found that GSI treatment resulted in necrosis as well as apoptosis in tumors generated by the xenotransplanted KSHV positive PEL cell lines. In contrast, GSI had no effect on mice harboring BJAB cells, a KSHV negative Burkitt’s lymphoma cell line where ICN levels were negligible. Our study provides further evidence to suggest that targeted downregulation of abnormal Notch signaling has therapeutic potential for KSHV related primary effusion lymphomas.