Summary: Brain creatine kinase (CK)-catalyzed phos phorus flux from phosphocreatine (PC) to ATP was mea sured in vivo in young adult mice made reversibly hyp oxic by injection of cyanide. Phosphorus spectra and sat uration transfer measurements of CK-catalyzed flux were acquired using a high-field (8.45 T) nuclear magnetic res onance (NMR) spectrometer. After low cyanide doses (1-3 mg/kg of body weight), there were no measurable changes in brain pH or in concentrations of PC, the nu cleoside triphosphates (including ATP), and Pi' The CK catalyzed phosphorus flux increased about 75% after the low cyanide dose. Higher doses (4-6 mg/kg) produced a
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