In this work, we propose a diffusion MRI protocol for mining Parkinson's disease diffusion MRI datasets and recover robust disease-specific biomarkers. Using advanced high angular resolution diffusion imaging (HARDI) crossing fiber modeling and tractography robust to partial volume effects, we automatically dissected 50 white matter (WM) fascicles. These fascicles connect deep nuclei (thalamus, putamen, pallidum) to different cortical functional areas (associative, motor, sensorimotor, limbic), basal forebrain and substantia nigra. Then, among these 50 candidate WM fascicles, only the ones that passed a test-retest reproducibility procedure qualified for further tractometry analysis. Leveraging the unique 2-timepoints test-retest Parkinson's Progression Markers Initiative (PPMI) dataset of over 600 subjects, we found statistically significant differences in tract profiles along the subcortico-cortical pathways between Parkinson's disease patients and healthy controls. In particular, significant increases in FA, apparent fiber density, tract-density and generalized FA were detected in some locations of the nigro-subthalamo-putaminal-thalamo-cortical pathway. This connection is one of the major motor circuits balancing the coordination of motor output. Detailed and quantifiable knowledge on WM fascicles in these areas is thus essential to improve the quality and outcome of Deep Brain Stimulation, and to target new WM locations for investigation.

Brainstorm is a free, open-source Matlab and Java application for multimodal electrophysiology data analytics and source imaging [primarily MEG, EEG and depth recordings, and integration with MRI and functional near infrared spectroscopy (fNIRS)]. We also provide a free, platform-independent executable version to users without a commercial Matlab license. Brainstorm has a rich and intuitive graphical user interface, which facilitates learning and augments productivity for a wider range of neuroscience users with little or no knowledge of scientific coding and scripting. Yet, it can also be used as a powerful scripting tool for reproducible and shareable batch processing of (large) data volumes. This article describes these Brainstorm interactive and scripted features via illustration through the complete analysis of group data from 16 participants in a MEG vision study.

We present a simple, reproducible analysis pipeline applied to resting-state magnetoencephalography (MEG) data from the Open MEG Archive (OMEGA). The data workflow was implemented with Brainstorm, which like OMEGA is free and openly accessible. The proposed pipeline produces group maps of ongoing brain activity decomposed in the typical frequency bands of electrophysiology. The procedure is presented as a technical proof of concept for streamlining a broader range and more sophisticated studies of resting-state electrophysiological data. It also features the recently introduced extension of the brain imaging data structure (BIDS) to MEG data, highlighting the scalability and generalizability of Brainstorm analytical pipelines to other, and potentially larger data volumes.

Abstract-Assessing the performance of electrical impedance tomography (EIT) systems usually requires a phantom for validation, calibration or comparison purposes. This paper describes a resistive mesh phantom to assess the performance of EIT systems while taking into account cabling stray effects similar to in vivo conditions. This phantom is built with 340 precision resistors on a printed circuit board (PCB) representing a 2D circular homogeneous medium. It also integrates equivalent electrical models of the Ag/AgCl electrode impedances. The parameters of the electrode models were fitted from impedance curves measured with an impedance analyzer. The technique used to build the phantom is general and applicable to phantoms of arbitrary shape and conductivity distribution. We describe three performance indicators that can be measured with our phantom for every measurement of an EIT data frame: signal-to-noise ratio, accuracy, and modeling accuracy. These performance indicators were evaluated on our EIT system under different frame rates and applied current intensities. The performance indicators are dependent on frame rate, operating frequency, applied current intensity, measurement strategy, and inter-modulation distortion when performing simultaneous measurements at several frequencies. These parameter values should therefore always be specified when reporting performance indicators to better appreciate their significance.Index Terms-Electrical impedance tomography, biomedical instrumentation, resistive mesh phantom.

The methods for electrophysiology in neuroscience have evolved tremendously over the recent years with a growing emphasis on dense-array signal recordings. Such increased complexity and augmented wealth in the volume of data recorded, have not been accompanied by efforts to streamline and facilitate access to processing methods, which too are susceptible to grow in sophistication. Moreover, unsuccessful attempts to reproduce peer-reviewed publications indicate a problem of transparency in science. This growing problem could be tackled by unrestricted access to methods that promote research transparency and data sharing, ensuring the reproducibility of published results. Here, we provide a free, extensive, open-source software that provides data-analysis, data-management and multi-modality integration solutions for invasive neurophysiology. Users can perform their entire analysis through a user-friendly environment without the need of programming skills, in a tractable (logged) way. This work contributes to open-science, analysis standardization, transparency and reproducibility in invasive neurophysiology.

We consider the problem of an operator controlling a fleet of electric vehicles for use in a ride-hailing service. The operator, seeking to maximize profit, must assign vehicles to requests as they arise as well as recharge and reposition vehicles in anticipation of future requests. To solve this problem, we employ deep reinforcement learning, developing policies whose decision making uses [Formula: see text]-value approximations learned by deep neural networks. We compare these policies against a reoptimization-based policy and against dual bounds on the value of an optimal policy, including the value of an optimal policy with perfect information, which we establish using a Benders-based decomposition. We assess performance on instances derived from real data for the island of Manhattan in New York City. We find that, across instances of varying size, our best policy trained with deep reinforcement learning outperforms the reoptimization approach. We also provide evidence that this policy may be effectively scaled and deployed on larger instances without retraining.

16The methods for electrophysiology in neuroscience have evolved tremendously over the recent 17 years with a growing emphasis on dense-array signal recordings. Such increased complexity and 18 augmented wealth in the volume of data recorded, have not been accompanied by efforts to 19 streamline and facilitate access to processing methods, which too are susceptible to grow in 20 sophistication. Moreover, unsuccessful attempts to reproduce peer-reviewed publications 21 indicate a problem of transparency in science. This growing problem could be tackled by 22 unrestricted access to methods that promote research transparency and data sharing, ensuring 23 the reproducibility of published results. 24 Here, we provide a free, extensive, open-source software that provides data-analysis, data-25 management and multi-modality integration solutions for invasive neurophysiology. Users can 26 perform their entire analysis through a user-friendly environment without the need of 27 programming skills, in a tractable (logged) way. This work contributes to open-science, analysis 28 standardization, transparency and reproducibility in invasive neurophysiology. 29 30 31 32 33

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