The ability to suppress distractions is essential to successful completion of goal-directed behaviors. Several behavioral studies have recently provided strong evidence that learned suppression may be particularly efficient in reducing distractor interference. Expectations about a distractor's repeated location, color, or even presence is rapidly learned and used to attenuate interference. In this study, we use a visual search paradigm in which a color singleton, which is known to capture attention, occurs within blocks with high or low frequency. The behavioral results show reduced singleton interference during the high compared to the low frequency block (Won et al., 2019). The fMRI results provide evidence that the attenuation of distractor interference is supported by changes in singleton, target, and non-salient distractor representations within retinotopic visual cortex. These changes in visual cortex are accompanied by findings that singleton-present trials compared to non-singleton trials produce greater activation in bilateral parietal cortex, indicative of attentional capture, in low frequency, but not high frequency blocks. Together, these results suggest that the readout of saliency signals associated with an expected color singleton from visual cortex is suppressed, resulting in less competition for attentional priority in frontoparietal attentional control regions.

No abstract

Establishing the reproducibility of brain MRS is important for clinical studies so that researchers can evaluate changes in metabolites due to treatment or the course of a disease and better understand the brain in healthy and disordered states. Prior 7-T MRS reproducibility studies using the stimulated echo acquisition mode (STEAM) sequence have focused on the anterior cingulate cortex or posterior cingulate cortex and precuneus. The purpose of this study was to evaluate the reproducibility of metabolite measurements in the dorsolateral prefrontal cortex (DLPFC) using an ultrashort echo time (TE) STEAM sequence and automated voxel repositioning. Spectra were acquired during two scan sessions from nine subjects using the AutoAlign method for voxel repositioning. Reproducibility was evaluated with coefficients of variation (CVs) and percentage differences. The mean intrasubject CVs were less than 6% for the major metabolites glutamate, N-acetylaspartate, total creatine, total choline, and myo-inositol. The mean CVs were less than 20% for the smaller signals of GABA, glutamine, glutathione, and taurine. These results indicate that 7-T MRS using a STEAM sequence with ultrashort TE and automated voxel repositioning provides excellent reproducibility of metabolites in the DLPFC.

There are mixed results regarding the differentiation of neurofunctional correlates of spatial abilities. Previous studies employed complex environments or alternate memory tasks which could potentially add to inconsistencies across studies of navigation. To help elucidate the existing mixed findings, we conducted a study in a simplistic environment without a supplemental memory task in order to examine navigationally relevant neural function using fMRI. Participants completed a virtual navigation task where they learned the relationship between landmarks, environmental features, and a goal. The goal was a distinct landmark, or feature, consistently situated in one corner, or a geometric cue, of a rectangular room. Test trials varied the relationship of featural and geometric cues allowing insight into navigational strategies when using these cues and when the cues are in conflict. Behavioral results showed participants learned the task rapidly and utilized both landmark feature-based and environmental geometry-based strategies to locate the goal; preferring the feature-based strategy. Neuroimaging results provided evidence for activation in navigationally relevant regions, including the parahippocampus, caudate, and retrosplenial cortex. These results demonstrate the importance of these structures and their relation to environmental geometry and feature use while navigating an enclosed simplistic environment. The results provide clarification regarding the role of the parahippocampus and caudate when using geometric- or landmark-based strategies and demonstrate the prerequisite of environmental novelty to elicit hippocampal activation.

The ability to suppress distractions is essential to successful completion of goal-directed behaviors. Several behavioral studies have recently provided strong evidence that learned suppression may be particularly efficient in reducing distractor interference. Expectations about a distractor’s repeated location, color, or even presence is rapidly learned and used to attenuate interference. In this study, we use a visual search paradigm in which a color singleton, which is known to capture attention, occurs within blocks with high or low frequency. The behavioral results show reduced singleton interference during the high compared to the low frequency block (Won et al., 2019). The fMRI results provide evidence that the attenuation of distractor interference is supported by changes in singleton, target, and non-salient distractor representations within retinotopic visual cortex. These changes in visual cortex are accompanied by findings that singleton-present trials compared to non-singleton trials produce greater activation in bilateral parietal cortex, indicative of attentional capture, in low frequency, but not high frequency blocks. Together, these results suggest that the readout of saliency signals associated with an expected color singleton from visual cortex is suppressed, resulting in less competition for attentional priority in frontoparietal attentional control regions.