SUMMARY Sixty‐seven TB horses in Britain suffering from clinical wobbler disease were divided into 5 groups, based on the presence or absence of pathological lesions and their nature. These groups were compared genetically with a control group of 67 TBs known not to exhibit signs of wobbling. Though analysed for both simple and complex modes of inheritance no evidence of a genetic basis was found in any group. The high breed incidence in TBs may be real or apparent. Considerably more male than female wobblers are reported. Other forms of possibly inherited ataxia in equidae are reviewed and reference is made to pathologically comparable conditions occurring in man and in the large breeds of dogs. RÉSUMÉ 67 chevaux de Pur Sang montrant les signes cliniques du Mal de Chien furent divisés en 5 groupes en fonction de la présence ou de l'absence de lésions pathologiques et compte tenu de la nature de ces lésions. Ces groupes furent comparés du point de vue génétique avec un groupe de référence de 67 Pur Sang connus comme n'ayant jamais montrés les signes cliniques du Mal de Chien. Aucune évidence d'un support héréditaire de la maladie ne fut trouvé dans aucun des groupes qu'il s'agisse de transmission directe ou indirecte. La fréquence élevée de cette affection chez le Pur Sang n'est peut être qu'une apparence. On constate que les mâles sont plus souvent atteints que les femelles. On passe en revue les autres formes d'ataxie héréditaire chez le Cheval en les comparant à des phénomènes analogues connus pour se produire chez l'Homme et chez les chiens de grande taille. ZUSAMMENFASSUNG 67 Vollblüter, klinisch als “Wobbler” (spinale Ataxie) beurteilt, wurden in 5 Gruppen eingeteilt, je nach dem Vorhandensein oder dem Fehlen von Laesionen und deren Natur. Diese Gruppen wurden genetisch verglichen mit einer Kontrollgruppe von 67 Vollblütern, die keine Anzeichen einer spinalen Ataxie aufwiesen. Trotz einer Analyse einfacher und komplexer Vererbungsmechanismen konnten in keiner Gruppe Anhaltspunkte für eine genetische Grundlage gewonnen werden. Die hohe Rassenfrequenz bei Vollblütern mag real oder nur scheinbar sein. Es werden erheblich häufiger männliche Wobbier gemeldet als weibliche. Andere, möglicherweise hereditäre Ataxien beim Pferd werden besprochen und es wird hingewiesen auf pathologisch vergleichbare Zustände beim Mensch und grossen Hunderassen.
Study of the pedigrees of a population of normal and epileptic Alsatians has revealed that there is a genetic basis for the condition in this breed, and that this basis is more complex than has hitherto been suggested. A preponderance of males is affected and there is strong evidence for additive factors determining the age at which animals first show clinical signs, and for the effect of one or more major genes. Only an objective test‐mating programme is likely to delineate the true mode of inheritance.
The examination of approximately 800 pure bred and cross bred Charolais cattle indicated that ocular colobomata is inherited via an autosomal dominant gene in this breed. Penetrance was found to be complete in the male and partial (52 per cent) in the female. Inheritance in the crossbred animals was different to that in the pure bred.
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