401: The Calculation of Inbreeding Coefficients

Falco, Marsha J.

doi:10.2307/2529827

Cited by 9 publications

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“…The pedigree details were entered into the IBM 3081 computer of Cambridge University and the program of Falco (1975) was used to calculate inbreedings and identify common ancestors (those animals which are found on both paternal and maternal sides of the pedigree). The simplest hypothesis, that the condition was due to or closely linked with a single autosomal gene, was tested by assuming that both parents of an epileptic pup were themselves carriers, heterozygous for the normal and the 'fitter' gene.…”

Section: Genetic Investigationsmentioning

confidence: 99%

Canine epilepsy: a genetic counselling programme for keeshonds

Hall¹,

Wallace

1996

Veterinary Record

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The predisposition of keeshonds (Dutch barge dogs) to an idiopathic epilepsy appears to be determined by a single autosomal recessive gene. The pedigrees of 15 litters which included animals diagnosed as epileptic ('fitters') were compared with those of 34 contemporary, normal animals. The pedigrees of all the fitters traced back, on both the paternal and maternal sides, to a common ancestor. Subsequently, further pedigrees and details of litters were gathered. If both parents of a fitter were heterozygous ('carriers'), the progeny (120 in number) of all known carrier x carrier matings would be expected to have a ratio of three phenotypically normal animals to one fitter, that is, 90:30. The ratio observed (91:29) was not significantly different. The Keeshond Club has published a list from which the identities of carriers can be inferred, with the intention that known carriers should be excluded from breeding. A genetic counselling programme has been in operation since 1989, which is based on advising breeders on the probability that the offspring of proposed matings would be fitters or carriers; advice has been given on 77 proposed matings. The mean probability that the proposed matings would result in carriers has declined significantly, and this is consistent with a decline in the frequency of the gene for this form of epilepsy in the breed.

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Section: Genetic Investigationsmentioning

confidence: 99%

Canine epilepsy: a genetic counselling programme for keeshonds

Hall¹,

Wallace

1996

Veterinary Record

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“…Further pedigree analysis was undertaken to determine if the data were consistent with a simple autosomal recessive, or a dominant gene either partially or fully penetrant, and if sex-linkage was involved. The groups were compared in terms of their inbreeding coefficients (F) obtained by a computer method (Falco, 1975); a oneway analysis of variance (ANOVA) compared the total average F value of each group with the control group.…”

Section: Group VImentioning

confidence: 99%

An Investigation into the Genetics of ‘Wobbler Disease’ in Thoroughbred Horses in Britain

Falco

Whitwell

Palmer

1976

Equine Veterinary Journal

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SUMMARY Sixty‐seven TB horses in Britain suffering from clinical wobbler disease were divided into 5 groups, based on the presence or absence of pathological lesions and their nature. These groups were compared genetically with a control group of 67 TBs known not to exhibit signs of wobbling. Though analysed for both simple and complex modes of inheritance no evidence of a genetic basis was found in any group. The high breed incidence in TBs may be real or apparent. Considerably more male than female wobblers are reported. Other forms of possibly inherited ataxia in equidae are reviewed and reference is made to pathologically comparable conditions occurring in man and in the large breeds of dogs. RÉSUMÉ 67 chevaux de Pur Sang montrant les signes cliniques du Mal de Chien furent divisés en 5 groupes en fonction de la présence ou de l'absence de lésions pathologiques et compte tenu de la nature de ces lésions. Ces groupes furent comparés du point de vue génétique avec un groupe de référence de 67 Pur Sang connus comme n'ayant jamais montrés les signes cliniques du Mal de Chien. Aucune évidence d'un support héréditaire de la maladie ne fut trouvé dans aucun des groupes qu'il s'agisse de transmission directe ou indirecte. La fréquence élevée de cette affection chez le Pur Sang n'est peut être qu'une apparence. On constate que les mâles sont plus souvent atteints que les femelles. On passe en revue les autres formes d'ataxie héréditaire chez le Cheval en les comparant à des phénomènes analogues connus pour se produire chez l'Homme et chez les chiens de grande taille. ZUSAMMENFASSUNG 67 Vollblüter, klinisch als “Wobbler” (spinale Ataxie) beurteilt, wurden in 5 Gruppen eingeteilt, je nach dem Vorhandensein oder dem Fehlen von Laesionen und deren Natur. Diese Gruppen wurden genetisch verglichen mit einer Kontrollgruppe von 67 Vollblütern, die keine Anzeichen einer spinalen Ataxie aufwiesen. Trotz einer Analyse einfacher und komplexer Vererbungsmechanismen konnten in keiner Gruppe Anhaltspunkte für eine genetische Grundlage gewonnen werden. Die hohe Rassenfrequenz bei Vollblütern mag real oder nur scheinbar sein. Es werden erheblich häufiger männliche Wobbier gemeldet als weibliche. Andere, möglicherweise hereditäre Ataxien beim Pferd werden besprochen und es wird hingewiesen auf pathologisch vergleichbare Zustände beim Mensch und grossen Hunderassen.

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“…Statistical tests were performed as appropriate (Helwig & Council 1979; Sokal& Rohlf 1981). The computer program described by Falco (1975) was used to compute inbreeding coefficients, following pedigrees back for up to six generations.…”

Section: Methodsmentioning

confidence: 99%

Breed Structures of for Conservation of Middle Rare Pigs: Implications the Berkshire, Tamworth, White, Large Black, Gloucester Old Spot, British Saddleback, and British Lop

Hall¹

1989

Conservation Biology

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Registration details of seven rare British breeds of pig w e studied over the period 1978–1986 inclusive. For four breeds, numbers of pigs registered have shown a slight upward trend. About 70% of males and 40% of females that breed, do so in herds other than the natal herd In the breed for which most pedigree data were analysed (the British Lop), 95–100% of recent pig crops were inbred In the rare breeds generally, mean inbreeding at around 6% signifies an inbreeding rate of about 1 % per generation, higher than has been found in commercial breeds. Breeds did not differ greatly in the ways they were structured. About a third of herds supplied boars to other herds, a relatively high proportion, indicating that the breeds have a structure that is not completely hierarchical, and this is favorable for genetic conservation. Pigs whose parents were from different herds were significantly less inbred than those with both parents from the same herd In some breeds it was clear that pigs sharing the same bloodline name were more closely related than pigs within the same herd but with different bloodline names. Conservation procedures applied to these pigs have been designed to conform with the customs and procedures of the British pedigree livestock industry. The most important single such procedure is the registration, with a central authority, of breeding stock.

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401: The Calculation of Inbreeding Coefficients

Cited by 9 publications

References 0 publications

Canine epilepsy: a genetic counselling programme for keeshonds

Canine epilepsy: a genetic counselling programme for keeshonds

An Investigation into the Genetics of ‘Wobbler Disease’ in Thoroughbred Horses in Britain

Breed Structures of for Conservation of Middle Rare Pigs: Implications the Berkshire, Tamworth, White, Large Black, Gloucester Old Spot, British Saddleback, and British Lop

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