Atopic dermatitis is associated with increased odds of ADD/ADHD in adults and children. Several factors increase the risk of ADHD in adults and children with AD.

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Children with severe atopic disease, accompanied by sleep disturbance, have higher risk of sedentary behaviors.

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Objective-To determine if eczema is associated with an increased risk of a speech disorder. Results-In multivariate survey logistic regression models adjusting for sociodemographics and comorbid allergic disease, eczema was significantly associated with higher odds of speech disorder in 12 of 19 cohorts (P < .05). The pooled prevalence of speech disorder in children with eczema was 4.7% (95% CI 4.5%-5.0%) compared with 2.2% (95% CI 2.2%-2.3%) in children without eczema. In pooled multivariate analysis, eczema was associated with increased odds of speech disorder (aOR [95% CI] 1.81 [1.57-2.05], P < .001). In a single study assessing eczema severity, mild (1.36 [1.02-1.81], P = .03) and severe eczema (3.56 [1.70-7.48], P < .001) were associated with higher odds of speech disorder. History of eczema was associated with moderate (2.35 [1.34-4.10], P = .003) and severe (2.28 [1.11-4.72], P = .03) speech disorder. Finally, significant interactions were found, such that children with both eczema and attention deficit disorder with or without hyperactivity or sleep disturbance had vastly increased risk of speech disorders than either by itself.Conclusions-Pediatric eczema may be associated with increased risk of speech disorder. Further, prospective studies are needed to characterize the exact nature of this association.Eczema is a chronic inflammatory skin disorder with highest prevalence in childhood, 1 which causes significant suffering because of itch, sleep disturbance, 2 and decreased quality of life. 3 Eczema is accompanied by profound systemic inflammation with activation of Thelper 2, 17, and 22 pathways. [4][5][6][7] Systemic inflammation and/or the strong burden of atopic Many studies have reported on the negative neurocognitive outcomes of various chronic diseases of childhood, particularly language ability. For example, chronic otitis media, 18,19 congenital heart disease, 20 and chronic kidney disease 21,22 have all have been associated with poor language and verbal performance in children. However, few studies have examined the neurocognitive ability of pediatric patients with eczema. Recently, we found that pediatric patients with eczema reported higher levels of contact with therapists, including speech therapists 23 suggesting that eczema affects in some way the functional speech capability of children. Children with eczema have multiple risk factors for speech and language disorders, including sleep disturbance 24,25 and ADHD. 26 We hypothesized that eczema is independently associated with increased risk of speech problems in children, particularly in severe eczema, sleep disturbance, and comorbid ADHD. The present study analyzed 19 US population-based cohorts to determine whether there is an association between eczema and speech disorders. HHS Public Access MethodsData were assessed from 19 different cohorts including the National Survey of Children's Health (NSCH) 2003-2004 and 2007-2008 and the National Health Interview Survey (NHIS) from the years 1997-2013. All surveys are collected...