The history of atopic dermatitis

Kramer, Owen N.; Strom, Mark A.; Ladizinski, Barry; Lio, Peter A.

doi:10.1016/j.clindermatol.2017.03.005

Cited by 34 publications

(18 citation statements)

References 22 publications

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“…AD has become a major health problem because its prevalence is increasing, it affects the quality of life, and it plays a role in the progression to other atopic diseases 1,2 . Because AD is a chronic disease with no cure, effective preventive measures are sought 31,32 .…”

Section: Discussionmentioning

confidence: 99%

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MicroRNA-155-5p is a key regulator of allergic inflammation, modulating the epithelial barrier by targeting PKIα

et al. 2019

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Recent studies have demonstrated that microRNA-155-5p (miR-155-5p) plays an essential role in the regulation of allergen-induced inflammation and is overexpressed in the skin of patients with atopic dermatitis (AD), although the mechanism is unknown. In this study, silencing miR-155-5p attenuated the thickening of the epidermis in AD model and reduced the infiltration of inflammatory cells and the secretion of Th2 cytokines. Protein kinase inhibitor α (PKIα) was identified as a direct target of miR-155-5p and correlated negatively with miR-155-5p in our AD model. Fluorescence in situ hybridization showed that miR-155-5p-expressing cells were predominantly present in the epidermis. When epithelial cells were transfected with an miR-155-5p inhibitor, the expression of PKIα, occludin, and CLDN16 increased and that of TSLP decreased significantly, whereas the overexpression of miR-155-5p resulted in the opposite changes. The increased expression of PKIα and tight junction (TJ) proteins, with reduced TSLP and IL-33, was also detected in miR-155-5p-blocked mice, in both the initial and elicitation stages of AD. The expression of TJ proteins also decreased when cells were transfected with PKIα siRNA. TJ proteins increased and TSLP and IL-33 decreased significantly after the overexpression of PKIα. Our data provide the first evidence that miR-155-5p is critical for the allergic inflammation in a mouse model of AD by directly regulating PKIα and thus epithelial TJ expression. These findings suggest new therapeutic strategies that target miR-155-5p in patients with allergic disorders.

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Section: Discussionmentioning

confidence: 99%

“…Atopic dermatitis (AD) is a common chronic inflammatory disease characterized by intense, dry pruritus, inflamed skin, and a relapsing and often chronic course 1,2 . Many of these features are attributed to an impaired skin barrier and a dysregulated immune response to a variety of triggers 3 .…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-155-5p is a key regulator of allergic inflammation, modulating the epithelial barrier by targeting PKIα

et al. 2019

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“…Только в 1892 г. Э. Бенье объединил разрозненные кожные болезни в одно заболевание, которое «меняет» свою клиническую картину с возрастом. Он дал новой болезни название «экземато-лихеноидная форма диатезического пруриго» [6,7]. В 1923 г. Артур Ф. Кока и Роберт А. Кук впервые использовали понятие «атопия» для описания аллергического ринита, крапивницы и астмы.…”

Section: исторический очеркunclassified

“…Macrolaminar desquamation and disruptions on hands of adolescent with atopic dermatitis Примечание (здесь и на рис. 4,7). АтД -атопический дерматит.…”

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The Role of Minor Signs in Atopic Dermatitis Diagnostics

Tamrazova

Селезнёв

Tamrazova

2020

Vopr. sovr. pediatr.

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General information on atopic dermatitis (AD), its history and epidemiological significance are presented. Multiple etiopathogenetic factors affecting disease manifestation are identified. The absence of specific tests, laboratory and histological studies, that can help in correct AT diagnosis, is mentioned. Most of AT diagnostic schemes clarify main (major) and additional (minor) signs of disease. Clinical manifestations of AD minor signs crucial for revealing of subacute and chronic course, as well as onset of incomplete remission of disease are described. Topical AD management regimens are presented. Pathogenetic verifications for emollients and regenerating agents use are presented.

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“…On the other hand, atopy (AT) is a “ predisposition toward developing certain allergic hypersensitivity reactions ” [ 14 , 15 ]. Atopy may have a genetic predisposition, although contact with an allergen or irritant may be a necessity, before a hypersensitivity reaction can develop [ 14 , 15 ]. The term atopy was first proposed by Coca & Cooke in 1923 [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Atopy in the Prevalence of Contact Sensitization: The Experience of a Greek Referral Center

Tagka

Lambrou

Nicolaidou

et al. 2020

Dermatology Research and Practice

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Contact dermatitis is a well-known skin condition, which is related to stimuli and environmental exposure to chemicals, affecting all ages as well as both genders. In the present work, we attempt to investigate the patterns of contact sensitization, with respect to the personal history of atopy (AT), in Greece in a large number of allergens, using patch testing. The retrospective analysis included clinical routine data of 1978 patients collected from 2014 to 2016 in the Laboratory of Patch Testing, National Referral Centre of Occupational Dermatoses. Sensitization, in all cases, was tested with 28 allergens of the European baseline series as adjusted to our local circumstances and clinical experience. A total population of 1978 patients was evaluated, with a male-to-female ratio of 0.45 (1359 females/619 males). From our patient cohort, 693 (35%) patients were evaluated with a history of atopy, while 1285 (65%) were nonatopic. The five most prevalent allergens in the total population without AT were nickel sulphate 5% (15.47%), fragrance mix (I) 8% (9.10%), balsam of Peru (6.47%), cobalt chloride 1% (4.70%), and thiomersal 0.1% (4.10%). Respectively, in the total population with AT, the five most prevalent allergens were nickel sulphate 5% (10.36%), fragrance mix (I) 8% (5.11%), balsam of Peru (3.29%), thiomersal 0.1% (3.03%), and cobalt chloride 1% (2.78%). Contact dermatitis surveillance is of great importance towards the clinical and systematic understanding of the disease. Further studies should be directed towards that end, in order to facilitate more effective health policies.

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The history of atopic dermatitis

Cited by 34 publications

References 22 publications

MicroRNA-155-5p is a key regulator of allergic inflammation, modulating the epithelial barrier by targeting PKIα

MicroRNA-155-5p is a key regulator of allergic inflammation, modulating the epithelial barrier by targeting PKIα

The Role of Minor Signs in Atopic Dermatitis Diagnostics

The Effect of Atopy in the Prevalence of Contact Sensitization: The Experience of a Greek Referral Center

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