Dietary supplements of purified unconjugated isoflavones administered to humans in single doses exceeding normal dietary intake manyfold resulted in minimal clinical toxicity. Genistein and daidzein (free and total) were rapidly cleared from plasma and excreted in urine.

A single-dose administration of purified unconjugated isoflavones at amounts that exceed normal dietary intakes had minimal clinical toxicity in healthy postmenopausal women. The pharmacokinetic data suggest that chronic dosing at 12-24-h intervals would not lead to progressive accumulation of these isoflavones.

AIM To assess the accuracy of skinfold equations in estimating percentage body fat in children with cerebral palsy (CP), compared with assessment of body fat from dual energy X-ray absorptiometry (DXA).METHOD Data were collected from 71 participants (30 females, 41 males) with CP (Gross Motor Function Classification System [GMFCS] levels I-V) between the ages of 8 and 18 years. Estimated percentage body fat was computed using established (Slaughter) equations based on the triceps and subscapular skinfolds. A linear model was fitted to assess the use of a simple correction to these equations for children with CP. RESULTSSlaughter's equations consistently underestimated percentage body fat (mean difference compared with DXA percentage body fat )9.6 ⁄ 100 [SD 6.2]; 95% confidence interval [CI] )11.0 to )8.1). New equations were developed in which a correction factor was added to the existing equations based on sex, race, GMFCS level, size, and pubertal status. These corrected equations for children with CP agree better with DXA (mean difference 0.2 ⁄ 100 [SD=4.8]; 95% CI )1.0 to 1.3) than existing equations.INTERPRETATION A simple correction factor to commonly used equations substantially improves the ability to estimate percentage body fat from two skinfold measures in children with CP.Although accurate assessment of nutritional status for children with cerebral palsy (CP) is important from clinical and research perspectives, physical impairments and growth differences hinder evaluation and interpretation in this population. Difficulties in measurement of stature arise from altered body posture and fixed contractures that interfere with reliable estimation of height or recumbent length. Equations that estimate height from segmental measures 1 have been developed and are widely used. Additionally, it is possible to use specialized chair scales or weigh a child along with a caregiver. 2 These modifications have allowed clinicians to obtain reliable measures of height and weight. Despite these improvements in measurement ability, clinicians continue to have challenges in interpreting growth and nutritional status in children with CP.Because children with CP often have malnutrition associated with short stature, simple measurements of weight and height are not adequate to identify nutritional abnormalities. Known alterations in body composition in malnourished children with CP include increased total body water, depleted fat and muscle stores, short stature, and decreased bone density. [3][4][5] Reliable measures of weight and height have allowed the use of weight-for-height centiles and body mass index (BMI), but the validity of these measures in assessing nutritional status in children with CP has been called into question. 3 Reliable and valid methods that are also quick and readily available are needed to estimate fat mass (as an indicator of nutritional status) for research and to guide clinical care for children with CP because of the constraints described above. Dual-energy X-ray absorptiometry (DXA) is one m...

Supplementation with omega-3 fatty acids in combination with dietary and exercise counseling was well tolerated and reduced fasting triglyceride levels in patients receiving antiretrovirals. To what extent the increase in low-density lipoprotein cholesterol levels observed in patients assigned this intervention is attributable to omega-3 fatty acid supplementation and whether this increase attenuates any benefit in lowering triglyceride levels is unclear. Given these results, further investigation of omega-3 fatty acid supplementation for the treatment of hypertriglyceridemia in HIV-infected patients is warranted.