Randomized Study of the Safety and Efficacy of Fish Oil (Omega-3 Fatty Acid) Supplementation with Dietary and Exercise Counseling for the Treatment of Antiretroviral Therapy--Associated Hypertriglyceridemia

Abstract

Supplementation with omega-3 fatty acids in combination with dietary and exercise counseling was well tolerated and reduced fasting triglyceride levels in patients receiving antiretrovirals. To what extent the increase in low-density lipoprotein cholesterol levels observed in patients assigned this intervention is attributable to omega-3 fatty acid supplementation and whether this increase attenuates any benefit in lowering triglyceride levels is unclear. Given these results, further investigation of omega-3 fatty acid supplementation for the treatment of hypertriglyceridemia in HIV-infected patients is warranted.

Terapia nutricional nas alterações metabólicas em pessoas vivendo com HIV/aids

“…Intraevaluator and interevaluator reliability as well as measures of association were not reported in the articles. Dyslipidemia was reported in all studies, 1,2,4,8,[16][17][18] lipodystrophy / body composition changes in two, 1,8 and insulin resistance / glucose intolerance 1 and hypertension 8 in one (Table 1). …”

“…Of the seven studies included, four were conducted in the United States, 8,17,18 two in Canada, 1,2 one in France, 16 and one in Australia. 4 They were published from 2005 to 2009 (Table 1).…”

“…Lost-to-follow-up was reported in six studies. 1,2,4,8,16,17 The follow-up period ranged from 13 weeks to six months (Table 1).…”

“…8,17,18 (Table 1). Intraevaluator and interevaluator reliability as well as measures of association were not reported in the articles.…”

“…Supplementation with omega-3 signifi cantly reduced triglycerides in IG compared to controls in at least one time point during the study. 2,4,[16][17][18] This reduction was not dependent on the supplementation dosing (3, 6 or 9 g/day), dieting and exercising. The only study using a supplementation dose of 9 g/day of omega-3 showed the greatest reductions in triglycerides.…”