A UV spectrophotometric method was developed for determination of ceftiofur sodium in the drug substance and sterile powder for injection. The method validation, which yielded good results, included evaluation of the range, linearity, intraand interday precision, accuracy, recovery, specificity, robustness, LOQ, and LOD. The UV spectrophotometric determinations were performed at 292 nm. Good linearity was obtained between 2.5 and 20.0 g/mL. A prospective validation showed that the method is linear (r = 0.9999) and precise, with RSD values of 0.3 for product A and 0.4 for product B. The intraand interday precision values were <2 for all samples analyzed. Comparison of UV spectrophotometry and LC by analysis of variance and Student's t-test showed no significant difference between methodologies. Moreover, the accuracy and precision obtained with the UV method correlated well with the values obtained with the LC method, and this correlation suggests that UV spectrophotometric analysis can be an inexpensive, reliable, and less time-consuming alternative to chromatographic analysis. The results demonstrated the validity of the proposed method as a simple and useful alternative for the determination of ceftiofur in routine QC analyses.
The Putinga, Rio Grande do Sul, chondrite (fall, August 16, 1937), consists of major olivine (Fa24.8), orthopyroxene (Fs21.3), and metallic nickel‐iron (kamacite, taenite, and plessite); minor maskelynite (Ab81.0An12.4Or6.6) and troilite; and accessory chromite (Cm79.0Uv8.2Pc1.8Sp11.0) and whitlockite. Mineral compositions, particularly of olivine and orthorhombic pyroxene, as well as the bulk chemical composition, particularly the ratios of Fe°/Ni° (5.24), Fetotal/SiO2 (0.58), and Fe°/Fetotal (0.27), and the contents of Fetotal (22.42%) and total metallic nickel‐iron (7.25%) classify the meteorite as an L‐group chondrite. The highly recrystallized texture of the stone, with well‐indurated, poorly discernible chondrules; xenomorphic, well‐crystallized groundmass olivine and pyroxene; and the occurrence of poikilitic intergrowth of olivine in orthopyroxene suggest that Putinga belongs to petrologic type 6. Maskelynite of oligoclase composition was formed by solid state shock transformation of previously existing well‐crystallized plagioclase at estimated shock pressures of about 250–350 kbar. Thus, recrystallization (i.e., formation of well‐crystallized oligoclase) must have preceded shock transformation into maskelynite.
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