Polyhedral borane derivatives have been utilized in the treatment of boron neuron capture therapy (BNCT) for brain glioma, and much attention has been paid to search excellent biocompatible boron-rich composites for effective cancer BNCT therapy. In this study, we have exploited the self-assembly of the gold nanoclusters with carborane amino derivatives (GNCs-CB) for the precise bioimaging of cancer cells and targeted delivery of this carborane compound to the tumors. Our observations demonstrate that the GNCs-CB can readily realize accurate tumor imaging and long-term accumulation in tumor sites by EPR effect and nanometer size effect, and thus efficiently implement tumor-targeting delivery of the carborane derivative and facilitate the real-time fluorescent visualization monitoring of the carborane targeted delivery process. This makes it possible to realize the accurate location of the tumor by the carborane derivative and reduce the damage to normal tissues in the process of boron neutron capture therapy through imaging guided treatment.

A new approach to synthesis of functional derivatives of 7,8-dicarba-nido-undecaborate anion based on ring-opening of its cyclic oxonium derivatives [10-(CH 2 ) 4 O-7,8-C 2 B 9 H 11 ] and [10-O(CH 2 CH 2 ) 2 O-7,8-C 2 B 9 H 11 ] with various nucleophiles was developed. Both cyclic oxonium derivatives can be obtained as single isomers by reaction of the parent anion [7,8-C 2 B 9 H 12 ] -with mercury(II) chloride in the corresponding solvents. Mechanism of formation of the cyclic oxonium derivatives of 7,8-dicarba-nido-undecaborate anion was proposed. A series of 7,8-dicarba-nido-undecaborate derivatives with terminal carboxylic and azide functions were prepared by the ring-opening reactions of the cyclic oxonium derivatives with substituted phenolate and azide ions, respectively.

No abstract

No abstract