Carborane Derivative Conjugated with Gold Nanoclusters for Targeted Cancer Cell Imaging

Abstract

Polyhedral borane derivatives have been utilized in the treatment of boron neuron capture therapy (BNCT) for brain glioma, and much attention has been paid to search excellent biocompatible boron-rich composites for effective cancer BNCT therapy. In this study, we have exploited the self-assembly of the gold nanoclusters with carborane amino derivatives (GNCs-CB) for the precise bioimaging of cancer cells and targeted delivery of this carborane compound to the tumors. Our observations demonstrate that the GNCs-CB can readily realize accurate tumor imaging and long-term accumulation in tumor sites by EPR effect and nanometer size effect, and thus efficiently implement tumor-targeting delivery of the carborane derivative and facilitate the real-time fluorescent visualization monitoring of the carborane targeted delivery process. This makes it possible to realize the accurate location of the tumor by the carborane derivative and reduce the damage to normal tissues in the process of boron neutron capture therapy through imaging guided treatment.

Boron Chemistry for Medical Applications

“…Wang et al [106] reported the gold nanoclusters with carborane amino derivatives for the targeted delivery of the carborane compound to the tumors and precise bioimaging of cancer cells. They prepared carborane derivative (NH 2 NH 3 ) + [7-NH 2 (CH 2 ) 3 S-7,8-C 2 B 9 H 11 ]according to the literature [107], and stored it at -18 • C. Gold nanoclusters (GNCs) were freshly prepared and dispersed in PBS (pH 7.2).…”

“…Illustration of the bioimaging process for cancer cells using gold nanocluster with carborane derivative (reprint from Ref [106]…”

Functionalization of Gold Nanoparticles by Inorganic Entities

“…Electrochemical properties of these nanocomposites were also investigated [81,82]. The potential applications of carborane-based Au-NPs is extremely broad since examination of ion transport across biological membranes [83] or cancer applications [84] were notably developed.…”

“…They are considered nano-building blocks due to their diameters (1.5 nm), and are easily functionalized by one or several organic groups [45]. In The potential applications of carborane-based Au-NPs is extremely broad since examination of ion transport across biological membranes [83] or cancer applications [84] were notably developed.…”

Synthesis and biological evaluation of a new series of ortho-carboranyl biphenyloxime derivatives

“…This is a special large steric skeleton with a very strong hydrophobic structure. Therefore, improvement of the chemical structure can alter the stability, water solubility, and biological activity of compatibility and allow wider applications of carborane as a BNCT agent [ 6 – 9 ]. Boron neutron capture therapy (BNCT) was first proposed as a potential cancer therapy in 1936, based on the thermal neutron captured by 10 B atoms then produces a 4 He (α-particle) and a 7 Li ion [ 10 , 11 ].…”