A 54-year-old woman presented a lesion on the dorsum of the right hand. Routine laboratory tests were normal or negative. Histological examination revealed mucin deposits in the reticular dermis. The lesion cleared within 1 year without any treatment but biopsy. This case does not fit the diagnostic criteria of any known cutaneous mucinoses.
A patient is described who had typical pemphigus vegetans, according to clinical, histopathological and immunofluorescence criteria. To determine the specific molecules bound by antibodies in the serum of this patient, an immunoprecipitation analysis was performed with extracts of [14C]-amino acid labelled cultured normal human keratinocytes. The patient's serum precipitated the 130 kd and 85 kd polypeptides of the pemphigus vulgaris antigen, but also precipitated other polypeptides, the significance of which is not clear.
Two patients are described in whom myasthenia gravis was associated with systemic lupus erythematosus. The review of the literature shows that such association is not frequent and that it affects mostly women (6 women:1 man), and that myasthenia gravis usually precedes lupus erythematosus. Thymectomy was a precipitating factor in 25% of the cases. Most of those patients present with general symptoms rather than with dermatologic signs.
A patient on intravenous heparin is described who developed an acute hemorrhagic necrosis of her legs. Thrombi without vasculitis were seen in the dermal blood vessels. This appears to be the 4th reported case of skin necrosis after intravenous heparin at sites unrelated to injections. Skin necrosis after intravenous heparin should warn the dermatologist of a possible fatal outcome from myocardial or cerebral infarction.
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