Prevalence of stratified epithelium-specific antinuclear antibodies in 138 patients with lichen planus

Epithelial antigenic specificities of circulating autoantibodies in mucosal lichen planus

“…Stratified epithelium‐specific antinuclear antibodies have also been described in a subset of LP patients, regardless of the site of involvement (skin or mucosae) . These antibodies were originally described in chronic ulcerative stomatitis, a confusing name for an entity that perfectly mimics erosive oral LP and which differs from LP only in the distinctive speckled pattern seen in IgG staining of keratinocyte nuclei by direct IF in unaffected perilesional mucosa or skin .…”

“…Autoantibodies against type XVII collagen have been occasionally reported in mucosal LP, especially in patients with vulvar involvement . Autoantibodies with different specificities have also been described, namely against BP230 and different isoforms of the tumor suppressor gene p53 family proteins, including the chronic ulcerative stomatitis antigen of 70‐kDa.…”

ELISA test for p63 antibodies in chronic ulcerative stomatitis

“…Some authors describe cases of clinical oral erosive LP with serum antibodies to a 70‐kDa keratinocyte antigen that they claim is the CUS antigen, although the protein was not sequenced or identified with a control monoclonal antibody to ΔNp63α. Thus, these authors claim the SES‐ANA pattern of autoantibodies is not exclusive to CUS (Parodi et al , 2007). Logically, however, if a patient has what is clinically erosive LP, and they have a positive SES‐ANA reaction on direct IF, then the accurate diagnosis should be CUS, not oral erosive LP (Solomon, 2008).…”

Chronic ulcerative stomatitis: A comprehensive review and proposal for diagnostic criteria

“…A group of researchers identified a 70-kDa antigen involved in CUS, ∆Np63α, which is a specific epithelial p63 isoform involved in the maturation of epithelial tissues in mammals (Lee et al, 1999;Parodi & Cardo, 1990;Parodi et al, 2000Parodi et al, , 1998. Although ∆Np63α, known as CUSP, is the CUS antigen, some authors have reported the same findings in erosive and non-erosive OLP (Cacciapuoti et al, 2004;Cozzani et al, 2008;Parodi et al, 2007), especially in vulvovaginal-gingival-pilar LP (Olszewska et al, 2016). Thus, IIF analysis alone is not conclusive for the diagnosis of CUS, while the DIF findings have been associated only with CUS and not with OLP, to date.…”