This study reports the obtainment of bioactive hydroxyapatite (HAp) extracted from scales of arowana fish (FSHA) (Osteoglossum bicirrhosum) by alkaline treatment followed by calcination at 600 and 800°C. The cell viability and bioactivity of hydroxyapatite particles (FSHA) were investigated and compared with those of HAp synthesized (s.HA) by the precipitation method. The HAp particles from fish scales showed non‐toxic behavior to dental pulp stem cells similar to HAp synthesized. Additionally, bioactivity assays show that the Hap from natural source forms the bone‐like apatite layer faster than s.HA sample, after being incubated in McCoy medium for 3 days. The results illustrate that HAp obtained from Osteoglossum bicirrhosum fish scale bio‐waste showed excellent biocompatibility. Besides, this study provides an effective method for converting low‐cost bio‐waste into a value‐added and it can be a potential alternative biomaterial for various biomedical applications.
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