The novel 11b-hydroxysteroid dehydrogenase type 1 (11b -HSD1) inhibitors known as sterenin A, B, C and D were found in a solid-state culture of the producing basidiomycetes identified as Stereum sp. SANK 21205. Purification of the 50% aq Me 2 CO extract of the culture was performed by EtOAc extraction, reversed phase opencolumn chromatography and successive ODS HPLC preparation. These compounds, whose structures were determined by several spectroscopic methods, were found to be novel isoindolinone alkaloids which exhibited potent selective inhibitory activities against 11b-HSD1.
Colletoic acid, a novel 11b -hydroxysteroid dehydrogenase type 1 (11b -HSD1) inhibitor, was found and isolated from the cultured broth of the producing fungus Colletotrichum gloeosporioides SANK 21404. Its structure was determined to be a novel acorene-type sesquiterpene by several spectroscopic methods. The absolute structure of colletoic acid was established using a modified Mosher's method and single-crystal X-ray diffraction analysis.
Alkaloids U 0600 Sterenin A, B, C and D, Novel 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors from Stereum sp. SANK 21205. -(ITO-KOBAYASHI, M.; AOYAGI, A.; TANAKA, I.; MURAMATSU, Y.; UMETANI, M.; TAKATSU*, T.; J. Antibiot. 61 (2008) 3, 128-135; Adv. Technol. Res. Lab.,
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