Purpose:To compare the diagnostic performance of breast lesions by the enhancement patterns and morphologic criteria on magnetic resonance imaging (MRI).
Materials and Methods:Both T1-weighted 3D gradientecho sequences with high temporal resolution and highspatial-resolution MRI were performed on 190 patients with a total of 204 enhancing lesions (144 malignant and 60 benign). The enhancement patterns and morphologic features of each mass and nonmass lesion were analyzed, and the diagnostic performance was compared.
Results:The sensitivity and specificity of the morphologic criteria were statistically significantly higher than those of the enhancement patterns (sensitivity: P ϭ 0.0012, specificity: P ϭ 0.0003), and the A z values for the three observers were 0.900, 0.919, and 0.900. The diagnostic accuracy of the morphologic criteria for both types of lesions was superior, and the differences were statistically significant (mass: P ϭ 0.0001, nonmass: P ϭ 0.0389).
Conclusion:The analysis of the morphologic features of enhancing breast lesions alone showed higher diagnostic performance; therefore, signal intensity (SI) time-course data may not be needed to diagnose malignant breast lesions.
Purpose:To investigate the effect of gadolinium (Gd)-DTPA on the apparent diffusion coefficient (ADC) of breast carcinoma and to analyze the relationship between pre/postcontrast ADC and the degree of contrast enhancement.
Materials and Methods:Nineteen histopathologically confirmed breast carcinomas (mean size ϭ 22 mm) were analyzed. Their ADCs before and after contrast administration were measured. The contrast-to-noise ratios (CNRs) of the tumors were measured on fat-suppressed 3D T1-weighted images in precontrast, early, and late postcontrast phases. These results were correlated with the measured ADC values.Results: A significant decrease in the measured ADC was noted after contrast administration (Ϫ23%, P ϭ 0.01). Lesions with relatively high ADC before contrast (Ͼ1.3 ϫ 10 Ϫ3 mm 2 /sec; n ϭ 12) demonstrated a larger degree of ADC reduction (mean 34%) than lesions with low ADC (Յ1.3 ϫ 10 Ϫ3 mm 2 /sec; n ϭ 7) (mean 4.5%). When an early postcontrast image was used as a surrogate marker of malignant potential, we found a significant inverse correlation with postcontrast ADC (␥ ϭ Ϫ0.57, P ϭ 0.02).
Conclusion:Postcontrast ADC exhibited lower values than precontrast ADC, which is thought to reflect suppression of the microperfusion-induced effect on diffusion-weighted imaging. Postcontrast ADC may be a better indicator than precontrast ADC to reflect malignant potential of tumors.
BACKGROUND AND PURPOSE:The Vim and VPL are important target regions of the thalamus for DBS. Our aim was to clarify the anatomic locations of the ventral thalamic nuclei, including the Vim and VPL, on MR imaging.
• Ultra-fast dynamic MRI effectively differentiates benign from malignant breast lesions. • Ultra-fast dynamic MRI contributes to BI-RADS categorisation in non-mass enhancement. • Management of non-mass breast lesions becomes more appropriate.
MR mammography permits more precise lesion assessment including ductal carcinoma in situ A correct diagnosis of occult invasion before treatment is important for clinicians This study showed the potential of MR mammography to diagnose occult invasion Treatment and/or aggressive biopsy can be given with greater confidence MR mammography can lead to more appropriate management of patients.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.