Over the past 20 years, incentives of the Orphan Drug Act (ODA), the largest single source of extramural clinical grants at the US Food and Drug Administration, have had a substantial impact on public health. ODA incentives have contributed to the development of many innovative biotechnology products, and as our understanding of the human genome evolves, it is anticipated that pharmacogenomics will result in the identification of more 'orphan diseases'.
Abstract. In order to meet customer requirements, technology developments need to stay focused at process rationalization and quality improvements. Combining the twin-roll casting technology and caliber rolling technology for magnesium wire, customer demands concerning cost-efficiency and high quality could be satisfied. For this purpose, the paper analyzes potential application fields and their demanded quality properties. Special requirements of illustrative magnesium long products are shown by adapting existing specifications of aluminum wire. The resulting long products could be applied in the automotive industry and aircraft sector as joining and welding elements or in biomedicine as screws. Finally, the innovative magnesium wire production technology will be explained and the advantages, in particular the resource efficiency, of the developed technology will be discussed.
Since 2018, the institute of metal forming has been studying the novel twin-roll casting (TRC) of magnesium wire at the pilot research plant set up specifically for this purpose. Light microscopic and scanning electronic investigations were carried out within this work and show the unique microstructure of twin-roll cast AZ31 magnesium alloy with grain sizes of about 10 μm ± 4 μm in centre and 39 μm ± 26 μm near the surface of the sample. By means of a short heat treatment (460 °C/15 min), segregations can be dissolved and grain size changes in centre to 19 μm ± 12 μm (increase) and near the surface to 12 μm ± 7 μm (decrease). Further, the mechanical properties of the twin-roll cast and heat-treated wire were analysed by tensile testing at room temperature. By heat treatment, the total elongation could be increased by a third whereas the strength decreases slightly. In heat-treated state, no preferred orientation is evident. In addition to the twin-roll cast and the heat-treated condition, the rolled state was analysed. For this purpose, the twin-roll cast wire was hot rolled using an oval-square calibration. After hot rolling, a dynamic recrystallization and grain refinement of the twin-roll cast wire could be achieved. It can be seen, that an increase in strength as well as in total elongation occur after wire rolling. Beside this, a rolling texture is evident.
Magnesium sheets are used for wide-ranging applications in the automotive sector. In contrast to conventional magnesium processing routes for strips, twin-roll casting (TRC) and hot rolling is a cost-efficient production process for magnesium strips and sheets. As part of previous research strategies, the optimization of the thermomechanical treatment of magnesium alloys has resulted in excellent mechanical properties for the component design. However, the previously determined results at room temperature cannot be correlated with the warm forming behaviour during the component production. This is due to different deformation mechanisms, which are active at various temperatures. For TRC material, there is a lack of knowledge about the influence of heat-treatment and rolling on the final mechanical properties at hot working temperatures. This article depicts the investigations done on the influence of heat-treatment and hot rolling conditions on the mechanical properties of AZ31 strips at tensile deformation temperatures of 20 °C and 300 °C.
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