A general
and efficient iodine-catalyzed metal-free oxidative cross-coupling
reaction of methyl ketones with 2-(1
H
-benzo[
d
]imidazol-2-yl)aniline has been established. This is a
new synthetic strategy for the synthesis of benzimidazo[1,2-
c
]quinazoline derivatives involving C(sp
3
)–H
oxidation, condensation, and cyclization processes.
A general and efficient TsOH mediated reaction of o-aminobenzamides with enaminone via CÀN and CÀC bond cleavage leading to quinazolinones has been achieved. This strategy involves CÀN/CÀC bond cleavage and CÀN bond formation in a single operation. Highlight of this work is associated metal free, peroxide free and base free reaction condition. All the synthesized compounds were characterized by NMR and ESI-MS spectral studies.[a] S.
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