A general
and efficient iodine-catalyzed metal-free oxidative cross-coupling
reaction of methyl ketones with 2-(1
H
-benzo[
d
]imidazol-2-yl)aniline has been established. This is a
new synthetic strategy for the synthesis of benzimidazo[1,2-
c
]quinazoline derivatives involving C(sp
3
)–H
oxidation, condensation, and cyclization processes.
A general and efficient TsOH mediated reaction of o-aminobenzamides with enaminone via CÀN and CÀC bond cleavage leading to quinazolinones has been achieved. This strategy involves CÀN/CÀC bond cleavage and CÀN bond formation in a single operation. Highlight of this work is associated metal free, peroxide free and base free reaction condition. All the synthesized compounds were characterized by NMR and ESI-MS spectral studies.[a] S.
A series of novel pyrrole derivatives has been synthesized from readily available acetophenone, N,N-dimethylformamaide dimethyl acetal, aniline, arylglyoxal and malanonitrile in methanol under reflux condition.This one pot reaction constitutes a new and rapid construction of a library of pyrroles. The synthesized compounds are characterized by spectral techniques and single crystal X-ray study.
The regioselective synthesis of benzo[4,5]imidazo[2,1-b]thiazole derivatives via amination (C–N) and intramolecular cyclization (C–S) reactions in the presence of molecular iodine has been reported. This method is base and metal free and features inexpensive catalysts, with a simple procedure and a short reaction time.
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