No abstract

This review about the proactive sequential therapy (PST) of external genital and perianal warts (EGW) is based on the most current available clinical literature and on the broad clinical experience of a group of international experts, physicians who are well versed in the treatment of human papillomavirus-associated diseases. It provides a practical guide for the treatment of EGW, including epidemiology, etiology, clinical appearance, and diagnostic procedures for these viral infections. Furthermore, the treatment goals and current treatment options, elucidating provider- and patient-applied therapies, and the parameters driving treatment decisions are summarized. Specifically, the mode of action of the topical treatments sinecatechins and imiquimod, as well as the PST for EGW to achieve rapid and sustained clearance is discussed. The group of experts has developed a treatment algorithm giving healthcare providers a practical tool for the treatment of EGW which is very valuable in the presence of many different treatment options.

No abstract

Background The cutaneous manifestations of SARS-CoV-2 have been insufficiently covered in the literature. Methods We retrospectively analyzed 39 patients, admitted in our hospital, all with confirmed SARS-CoV-2 infection, patients that associated during the hospitalization or in the convalescence period various skin manifestations. Results We admitted in our hospital from March 23 until September 12, 2020, 39 cases of SARS-CoV-2 infected patients which were identified with intra-infectious rash or with lesions ofcutaneous vasculitis during convalescence. The most common cutaneous manifestation are erythematous and erythematous papular rash. 27 of the 39 documented patients had anosmia (69.2%), 26 patients had ageusia (66.7%), 34 patients presented pneumonia (87.2%), 24 patients had intra-infectious enterocolitis (61.5%). Skin biopsies were rarely performed in these patients. Furthermore, we are reporting two performed biopsies with the histopathological and immunohistochemistry changes of this selected cases of erythematous rash and erythema multiforme-like lesions. Both skin biopsies reveal an early fibrous remodeling of the dermis, suggesting similar changes that occur in the lungs or in other tissues in this disease. Conclusions The correlation of the skin lesions in SARS-CoV-2 infection with anosmia, ageusia and enteritis does not seem to be accidental, but associated with a similar response to ACE2 receptor expression in these tissues.

New Co(II), Ni(II), and Cu(II) complexes were synthesized with the Schiff base ligand obtained by the condensation of sulfathiazole with salicylaldehyde. Their characterization was performed by elemental analysis, molar conductance, spectroscopic techniques (IR, diffuse reflectance and UV–Vis–NIR), magnetic moments, thermal analysis, and calorimetry (thermogravimetry/derivative thermogravimetry/differential scanning calorimetry), while their morphological and crystal systems were explained on the basis of powder X-ray diffraction results. The IR data indicated that the Schiff base ligand is tridentate coordinated to the metallic ion with two N atoms from azomethine group and thiazole ring and one O atom from phenolic group. The composition of the complexes was found to be of the [ML2]∙nH2O (M = Co, n = 1.5 (1); M = Ni, n = 1 (2); M = Cu, n = 4.5 (3)) type, having an octahedral geometry for the Co(II) and Ni(II) complexes and a tetragonally distorted octahedral geometry for the Cu(II) complex. The presence of lattice water molecules was confirmed by thermal analysis. XRD analysis evidenced the polycrystalline nature of the powders, with a monoclinic structure. The unit cell volume of the complexes was found to increase in the order of (2) < (1) < (3). SEM evidenced hard agglomerates with micrometric-range sizes for all the investigated samples (ligand and complexes). EDS analysis showed that the N:S and N:M atomic ratios were close to the theoretical ones (1.5 and 6.0, respectively). The geometric and electronic structures of the Schiff base ligand 4-((2-hydroxybenzylidene) amino)-N-(thiazol-2-yl) benzenesulfonamide (HL) was computationally investigated by the density functional theory (DFT) method. The predictive molecular properties of the chemical reactivity of the HL and Cu(II) complex were determined by a DFT calculation. The Schiff base and its metal complexes were tested against some bacterial strains (Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Bacillus subtilis). The results indicated that the antibacterial activity of all metal complexes is better than that of the Schiff base.