Objective: to evaluate the quality of life of patients who underwent revascularization surgery. Method: a descriptive, crosssectional study, with quantitative approach carried out with 75 patients. The questionnaire WHOQOL-Bref was used to evaluate the quality of life (QOL). Results: patients' QOL evaluation presented a moderate result, with need of improvement of all domains. Low income patients had the worst evaluation of QOL in the domain environment (p=0,021), and the ones from Recife/metropolitan area, in the domain social relationship (p=0,021). Smoker (p=0,047), diabetic (p=0,002) and alcohol consumption (p=0,035) patients presented the worst evaluation of the physical domain. Renal patients presented the worst evaluation of QOL in the physical (P=0,037), psychological (p=0,008), social relationship (p=0,006) domains and total score (p=0,009). Conclusion: the improvement of QOL depends on the individual's process of behavioral change and the participation of health professionals is essential to formulate strategies to approach these patients, especially concerning health education. Descriptors: Quality of Life; Thoracic Surgery, Coronary Heart Disease; Chronic Disease; Nursing. RESUMO Objetivo: avaliar a qualidade de vida de pacientes submetidos à cirurgia de revascularização. Método: estudo descritivo, transversal, com abordagem quantitativa realizado com 75 pacientes. Foi utilizado o questionário WHOQOL-Bref para avaliação da qualidade de vida (QV). Resultados: Pacientes apresentaram avaliação da QV regular, com necessidade de melhora em todos os domínios. Pacientes de baixa renda tiveram pior avaliação da QV no domínio meio ambiente (p=0,021), e os procedentes de Recife/região metropolitana, no domínio relações sociais (p=0,021). Pacientes tabagistas (p=0,047), diabéticos (p=0,002) e etilistas (p=0,035) apresentaram pior avaliação da QV no domínio físico. Pacientes renais apresentaram pior avaliação da QV nos domínios físico (P=0,037), psicológico (p=0,008), relações sociais (p=0,006) e no escore total (p=0,009). Conclusão: a melhoria da QV depende de um processo de mudança de comportamento individual e a participação dos profi ssionais de saúde é essencial para elaborar estratégias de abordagem desses pacientes, principalmente no tocante à educação em saúde. Quality of life of patients who undergone myocardial revascularization surgery Araújo HVS, et al.

SUMMARY:This study investigated the immunodetection of PCNA in epithelial components of dental follicles associated with impacted third molars without radiographical and morphological signs of pathosis. A total of 105 specimens of dental follicles associated with impacted third molars with incomplete rhizogenesis (between Nolla's stage 6 and 9) were surgically removed from 56 patients. Epithelial cell proliferating was determined by using immunohistochemical labeling. Statistical analysis was performed using the Fisher exact test. Of the 105 dental follicles collected, 6 were PCNA-positive (≈ 6%). The specimens with squamous metaplasia and epithelial hyperplasia had higher rates of positivity for PCNA, as well as those with proliferative remnants of odontogenic epithelium. In conclusion, this study shows that dental follicles at this stage of development have low proliferative potential, but suggests that squamous metaplasia, hyperplasia of the epithelial lining and presence of proliferative odontogenic epithelial rests in the connective tissue may be early signs of developing lesions of odontogenic origin.

Introduction Warfarin continues to be the most widely used anticoagulant in clinical practice around the world for the prevention of thromboembolic events in patients with atrial fibrillation (AF). The evaluation of the quality of anticoagulation control, estimated by time in therapeutic range (TTR), is accepted as a good method to evaluate the quality of anticoagulation. The variability of TTR can be explained by the presence of variants of the CYP2C9 and VKORC1 genes. Methods This study examined the association between polymorphisms of the CYP2C9 and VKORC1 genes and control of oral anticoagulation, through TTR, in patients with AF. A cross-sectional study was conducted within a cohort follow-up. The study comprised of 317 patients with AF, using warfarin, who were followed up for one year. The genotyping of genes CYP2C9 (rs1057910), (rs1799853) and VKORC1 (rs923231) was performed by PCR in real time, using TaqMan probes. Results Patients who had variant genotypes for the CYP2C9*3 gene (rs1057910) presented higher TTR (TTR 81–100%) when compared to when compared to the <45% and 46–60% TTR groups ( p =0.005 and p =0.002, respectively). Regarding VKORC1 (rs923231), patients who had the variant genotype for the VKORC1 (rs923231) gene also presented a higher TTR (TTR 81–100%), when when compared to the <45% and 46–60% TTR groups ( p =0.005 and p =0.004, respectively). In a multivariate model, VKORC1 (rs923231) remained associated for comparisons with the TTR groups (<45% vs 81–100% groups, p =0.01; and 46–60% vs 81–100% groups, p =0.01). Conclusion The genotypes of the CYP2C9*3 (AA) and VKORC1 -1639 (GG) genes were associated with the worst quality of anticoagulation control (TTR) in patients with AF using warfarin in the northeast of Brazil.

SUMMARY:This study investigated the immunodetection of PTCH in epithelial components of dental follicles associated with impacted third molars without radiographic signs of pathosis. One hundred and five specimens of dental follicles associated with impacted third molars with incomplete rhizogenesis (between Nolla's stage 6 and 9) were surgically removed from 56 patients. Epithelial cell proliferation was determined by using immunohistochemical labeling. Statistical analysis was performed using Fisher exact test and a level of significance of 5%. Of the 105 dental follicles collected, 3 were PTCH-positive. The specimens with squamous metaplasia and epithelial hyperplasia had higher rates of positivity for PTCH, as well as those with active remnants of odontogenic epithelium. This study suggests that the odontogenic cells of the dental follicle might be proliferating during the rhizogenesis, while the squamous metaplasia and hyperplasia of the epithelial lining and proliferative odontogenic epithelial rests show the differentiation potential of dental follicles.

Objective: To assess the knowledge of patients receiving outpatient treatment on oral anticoagulant therapy. Method: Cross-sectional study with a quantitative approach, performed at the Emergency Hospital of Pernambuco (PROCAPE) with 100 individuals. We used specific instrument of 10 questions. Answers to scores assigned subsequently classified as insufficient knowledge, regular and adequate knowledge knowledge after cutoff. The study was approved by the Research Ethics Committee, CAAE nº30622114.2.0000.5192. Results: Only 39% of subjects had adequate knowledge about treatment. There was statistical significance in pools of knowledge with sex (p = 0.042), age (p = 0.015), years of education (p = 0.021) and average time of outpatient follow-up (p = 0.010). Conclusion: The prevalence of inadequate knowledge (61%) demonstrate the need to implement educational strategies that promote the understanding of the treatment, stimulating drug adherence and reducing possible complications

O trabalho da enfermagem exercido em uma Unidade de Terapia Intensiva Neonatal (UTIN) é um desafio constante, pois requer vigilância, habilidade, conhecimento e sensibilidade, uma vez que o paciente é bastante vulnerável e totalmente dependente da equipe que o assiste. O estudo teve como objetivo identificar os principais diagnósticos de enfermagem na UTIN presentes na literatura brasileira a partir do ano de 2009. Trata-se de um estudo de revisão integrativa, realizado na Biblioteca Virtual em Saúde, com os descritores UTI neonatal, diagnóstico de enfermagem e processo de enfermagem. Foram incluídos cinco artigos para análise. Os principais diagnósticos foram: Padrão ineficaz de alimentação do lactente; Integridade da pele prejudicada; Risco de infecção; Padrão respiratório ineficaz; Troca de gases prejudicada e Desobstrução ineficaz das vias aéreas. A identificação correta de tais diagnósticos pode subsidiar uma assistência de enfermagem mais efetiva.

Galectin-3 (Gal-3) is a biomarker of fibrosis that has been associated with atrial remodeling. Acknowledging the presence of a biomarker in patients with atrial fibrillation (AF) can allow for a better clinical treatment. The aim of this study was to assess the association of Gal-3 with atrial fibrosis in patients with AF. This is a systematic review study. From the total number of studies analyzed, 12 demonstrated a relation between atrial fibrosis and Gal-3 in patients with AF and presented statistically significant association values. We conclude that Gal-3 is associated with atrial fibrosis in patients with AF in all types, as well as after the arrhythmia treatment by ablation.

Objetivo: investigar la adherencia farmacológica y el conocimiento de pacientes en tratamiento con anticoagulantes orales con acompañamiento en ambulatorio. Método: estudio transversal con enfoque cuantitativo. Resultados: se evaluaron 222 pacientes; de ellos el 60,8 % se clasificaron como no adherentes, y el 63,1 % poseían conocimiento inadecuado sobre la anticoagulación oral. La no adhesión estaba relacionada con un tratamiento más prolongado (p < 0,001) y con los pacientes con valores da International Normalized Ratio (inr) fuera del rango terapéutico (p = 0,022). El conocimiento no adecuado se asoció al menor nivel educativo (p < 0,001), al sedentarismo (p = 0,027), al menor tiempo de acompañamiento en ambulatorio (p < 0,001) y a los pacientes con valores de inr fuera del rango terapéutico (p = 0,012 ). Conclusión: con base en los resultados se evidencia la necesidad de estrategias de educación en salud que atiendan a ese público, teniendo en cuenta la comprensión individual y la adhesión farmacológica como algo crucial en la terapia.