Most tumor and clinical features differed significantly between CP and RCT patients. These data raise concerns about the applicability of RCT results to CP patients.
Abstract. Metformin, the drug of choice in the treatment of type 2 diabetes mellitus (DM2), in addition to aspirin (ASA), the drug prescribed for cardioprotection of diabetic and non-diabetic patients, have an inhibitory effect on cancer cell survival. The present population-based study conducted in the province of Trieste (Italy), aimed to investigate the prevalence of DM2 in patients with colorectal adenocarcinoma (CRC) and survival for CRC in diabetic and nondiabetic patients. All permanent residents diagnosed with a CRC between 2004 and 2007 were ascertained through the regional health information system. CRC-specific and relative survival probabilities were computed for each group of patients defined by CRC stage, presence or absence of DM2 treated with metformin, and presence or absence of daily ASA therapy. A total of 515 CRC patients without DM2 and 156 with DM2 treated with metformin were enrolled in the study. At the time of CRC diagnosis, 71 (14%) nondiabetic and 39 (25%) diabetic patients were taking ASA daily. The five-year relative survival for stage III CRC was 101% [95% confidence interval (CI) =76-126] in the 18 patients with DM2 treated with metformin and ASA, 55% (95% CI=31-78) in the 23 without DM2 treated with ASA, 55% (95% CI=45-65) in the 150 without DM2 not taking ASA, and 29% (95% CI=13-45) in the 43 with DM2 treated with metformin, however not with ASA. The findings support the hypothesis of a possible inhibitory effect of metformin and ASA on CRC cells. Randomized controlled trials are required to verify this hypothesis.
Objetivos: apresentar resultados de estudo ergonômico do trabalho dos desinsetizadores, destacando-se avaliação do ruído, calor e medidas de controle durante aplicação de inseticidas com pulverizador costal motorizado. Métodos: Reuniões com equipes, video-gravação e análise da atividade através do método preconizado por Guerin et al. (2001). Avaliação quantitativa do ruído e ensaios para redução deste através de modificações no equipamento. Medição do IST durante a pulverização, estudo da perda de peso corpóreo de expostos e não-expostos à radiação solar, antes e depois da atividade. Exames médicos dos trabalhadores. Resultados: nível equivalente de ruído medido foi 97,5 dB(A) e em baixas freqüências acima de 100 dB. IBUTG de 29,37ºC, para um LT de 25,5ºC. Perda de peso dos expostos 2,31% em média e 1,71% para o grupo-controle. Conclusões: reestudos da forma de trabalho e de engenharia são necessários para redução de desgastes à saúde decorrentes da atividade e da concepção do equipamento.
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