The precise evaluation of patients with NSAIDs hypersensitivity following established guidelines will improve not only our understanding but also the management of these entities. As the number of patients affected with NSAIDs is important, further studies are warranted.
Background Beta-lactams generate different allergenic determinants that induce selective or cross-reactive drug hypersensitivity reactions (DHRs). We aimed to identify the drugs involved, the selectivity of the response, the mechanism, and the value of the different diagnostic tests for establishing a diagnosis in children evaluated for DHRs to beta-lactams. Methods Prospective study evaluating children aged under 16 years reporting DHRs to beta-lactams. Reactions were classified as immediate and nonimmediate reactions. The work-up included sIgE, skin testing and drug provocation tests (DPTs) for immediate reactions and patch testing and DPTs for nonimmediate ones. Results Of the 510 included children, 133 were evaluated for immediate reactions and confirmed in 8.3%. Skin test/in vitro IgE contributed to diagnosing half of the cases. Selective reactions occurred with amoxicillin (63%), followed by common penicillin determinants (27%) and cephalosporins (0.9%). Among nonimmediate reactions (11,4% of the 377 children evaluated), most required DPTs, 52.7% of which were positive at 6–7 days of drug challenge. Selective reactions were identified with amoxicillin (80%), penicillin G (7.5%), cephalosporins (7.5%), and clavulanic acid (5%). Urticaria and maculopapular exanthema were the most frequent entities. Conclusions There were few confirmed cases of either type of reaction. Skin testing proved less valuable in nonimmediate reactions, over half of which would also have been lost in a short DPT protocol. Selective responders to amoxicillin were more likely to have nonimmediate reactions, while clavulanic acid-selectivity was exclusive to the nonimmediate typology. Over half the cases with DPTs required 6-7 days of treatment for DHR confirmation.
RATIONALE: Common pollens in the south of Europe and Mediterranean area are olive, grass and parietaria pollen. Because in some areas there are great extensions of peach cultivar, our aim was to study if peach pollen was relevant. METHODS: The study was undertaken in a population specialized in peach cultivar located in the SouthEast of Spain. A clinical history plus prick testing was made with a panel of relevant inhalant allergens including peach pollen and with Pru p 3 and Pho d 2 (Profilin). RESULTS: We evaluated 1800 cases aged between 3 and 90 y.o. Prevalence of sensitisation was: olive 33%, grass pollen 26%, Salsola kali 19%, Cupresus 17% and Parietaria 13%. Peach pollen was 22%. The analysis of prevalence to peach stratified by six years intervals showed: in the first (3-8 y.o.) 6% with an increase to a maximum of 47% at the interval of 21-27 y.o. (P<0.001) From the total number of positive to peach pollen, the 40% was positive to Pru p 3. The clinical entities referred by the subjects were: rhinitis in 79% of the cases, asthma in 29%, urticaria in 24% and anaphylaxis in 18%. Most of the cases sensitized to peach pollen were also to the other pollens tested with only few cases monosensitised to peach pollen. CONCLUSIONS: Sensitisation and allergy to peach pollen must be evaluated in areas with a high cultivars. Because most of the patients are also sensitized to other pollens, the clinical relevance of peach tree pollen must be established.
RATIONALE: Rhintics allergyis a risk factor for the development of asthma, affects the quality of life, school, or work performance and impacts the family economy. This work was carried out to determine the behavior of rhintics allergy according to age and sex, sensitivity to allergy tests and the association with other allergic diseases. METHODS: A cross-sectional observational study that included patients attending the allergy clinic with symptoms of rhinitis (34.18% male and 65.81% female, mean age 31-45 years). In all cases, allergic clinical history and skin prick tests were performed. For demographic data, concomitant diseases and allergic symptoms, frequency tables were used for nominal variables. RESULTS: Of 1528 patients who were seen at the allergy clinic, 313 patients had rhintics allergy for 20.48%. The skin tests showed a greater sensitivity to the Dermatophagoides pteronyssinus with 42.49% in relation to the rest of the aeroallergens. 19.82% were associated with asthma, 12.10% with bronchial hyperreactivity. CONCLUSIONS: 20.48% of patients suffer from Allergic Rhinitis. Higher incidence in children under 15 years of age in males. Patients are more sensitive to the mite Dermatophagoides Pteronisino. Of the patients with allergic rhinitis 60% are associated with allergic conjunctivitis and 30% with bronchial asthma J ALLERGY CLIN IMMUNOL VOLUME 141, NUMBER 2 Abstracts AB127 SUNDAY
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