RATIONALE: Patients can be allergic to multiple substances due to IgEmediated recognition of similar epitopes on proteins from different sources. We applied cluster-detection techniques to food-allergic patient data to detect groups of cross-reactive allergens. Such groupings will be useful for patient-classification, diagnosis, treatment and discovery. METHODS: Skin prick test (SPT) results were obtained for confirmed food-allergic patients, for allergens common to Mediterranean areas. Patients/allergens with much missing data were excluded. Cluster analysis was performed using R/Cytoscape. Similarity was calculated using binary distance metrics. Patient self-reporting data was also obtained. RESULTS: Following exclusion, 525 participants and 45 agents were analysed. The allergens giving rise to the most positive SPT results were olive pollen, peach, tree-nuts/peanuts, grasses and house-dust mites. Cluster analysis found that similar allergen-sources tended to group together, including fruits, mites, nuts, dander, trees, weeds and grasses. Comparison with self-reported previous reactions showed high overlap, albeit with notable exceptions including lentils and sesame seeds. The choice of distance metric and clustering method influenced cluster-building. CONCLUSIONS: SPT analysis reveals patterns of co-reactivity between allergens. This information can aid diagnosis and suggest which allergensources to avoid. It can also guide studies of panallergens and epitope mapping. However, the choice of metric to calculate similarity is important: given the predominance of negative data, assymetric metrics are advised. Future work will investigate other geographical areas and patient IgE levels.
RATIONALE: Common pollens in the south of Europe and Mediterranean area are olive, grass and parietaria pollen. Because in some areas there are great extensions of peach cultivar, our aim was to study if peach pollen was relevant. METHODS: The study was undertaken in a population specialized in peach cultivar located in the SouthEast of Spain. A clinical history plus prick testing was made with a panel of relevant inhalant allergens including peach pollen and with Pru p 3 and Pho d 2 (Profilin). RESULTS: We evaluated 1800 cases aged between 3 and 90 y.o. Prevalence of sensitisation was: olive 33%, grass pollen 26%, Salsola kali 19%, Cupresus 17% and Parietaria 13%. Peach pollen was 22%. The analysis of prevalence to peach stratified by six years intervals showed: in the first (3-8 y.o.) 6% with an increase to a maximum of 47% at the interval of 21-27 y.o. (P<0.001) From the total number of positive to peach pollen, the 40% was positive to Pru p 3. The clinical entities referred by the subjects were: rhinitis in 79% of the cases, asthma in 29%, urticaria in 24% and anaphylaxis in 18%. Most of the cases sensitized to peach pollen were also to the other pollens tested with only few cases monosensitised to peach pollen. CONCLUSIONS: Sensitisation and allergy to peach pollen must be evaluated in areas with a high cultivars. Because most of the patients are also sensitized to other pollens, the clinical relevance of peach tree pollen must be established.
RATIONALE: Rhintics allergyis a risk factor for the development of asthma, affects the quality of life, school, or work performance and impacts the family economy. This work was carried out to determine the behavior of rhintics allergy according to age and sex, sensitivity to allergy tests and the association with other allergic diseases. METHODS: A cross-sectional observational study that included patients attending the allergy clinic with symptoms of rhinitis (34.18% male and 65.81% female, mean age 31-45 years). In all cases, allergic clinical history and skin prick tests were performed. For demographic data, concomitant diseases and allergic symptoms, frequency tables were used for nominal variables. RESULTS: Of 1528 patients who were seen at the allergy clinic, 313 patients had rhintics allergy for 20.48%. The skin tests showed a greater sensitivity to the Dermatophagoides pteronyssinus with 42.49% in relation to the rest of the aeroallergens. 19.82% were associated with asthma, 12.10% with bronchial hyperreactivity. CONCLUSIONS: 20.48% of patients suffer from Allergic Rhinitis. Higher incidence in children under 15 years of age in males. Patients are more sensitive to the mite Dermatophagoides Pteronisino. Of the patients with allergic rhinitis 60% are associated with allergic conjunctivitis and 30% with bronchial asthma J ALLERGY CLIN IMMUNOL VOLUME 141, NUMBER 2 Abstracts AB127 SUNDAY
Sensitization to airborne moulds may be a risk factor for severe asthma and fatal exacerbation METHODS: A prospective, one-year period (April 2016-March 2017), study looking at the patterns of sensitization to common allergens in relation to severe asthma exacerbation mong adult asthmatics who are coming in acute exacerbations at Al-Rashed Allergy Centre in Kuwait. Data were collected from patient's records (skin prick test, FEV1, ACT).Patients with FEV1<60% of predicted and ACT<15 were included. Daily counts of local pollens (Salsola kali, Bermuda grass) and moulds (Aspergilus, Alternaria and Cladosporium) were obtained from the aerobiology department. Daily metrological parameters (atmospheric pressure, temperature, humidity level, wind speed) were provided by Kuwait Environment Public Authority RESULTS: We had 676 patients with severe asthma exacerbation, 86.39% of them were atopic. Sensitization to pollens only and/or to moulds (mono and polysensitised) was found in 146(25.0%) of patients, while 13(2.23%) were monosensitized to moulds only.We had more exacerbations in patients sensitised to moulds (p<0.0) in February, and more patients sensitised to Salsola kali (p<0.05) in December. There was a significant positive correlation between total number of asthma patients and number of asthma exacerbations (Spearman r50,7343; 95CI: 0,2591 to 0,9233; p50.0087). However, the correlation between asthma exacerbations in patients monosensitised to mould only and to pollens only was not statistically significant (p5 0.5493). Temperature correlated significantly with allergens concentration. Atmospheric pressure correlated significantly with the concentration of Alternaria and Aspergilus CONCLUSIONS: Although the rate of allergen sensitization is high, moulds play a minor role in asthma exacerbation
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