BACKGROUND: Population aging is considered to be a global phenomenon today. Age-associated immune system dysfunction or “immunosenescence” is indicated by increased susceptibility to infections and chronic diseases, such as hypertension, diabetes mellitus, autoimmune diseases, heart disease, and atherosclerosis. One of the immunosenescence markers is a significant drop in CD28 and reduced proinflammatory cytokine interleukin-2 (IL-2). The mango mistletoes are deemed to have a better affinity for docking the CD28 and IL-2R receptors of α and β subunits than other plants.
AIM: This study aims to determine the effect of ethanol extract of mango mistletoes on IL-2 levels, the percentage of CD4+CD28+, and the percentage of CD8+CD28+ in aged female mice.
METHODS: The leaves of mango mistletoes were extracted using 96% ethanol solvent, and the extract was administered to aged female mice (18–20 months) orally with different doses for each group, namely 150, 300, and 600 mg/kg. Mango mistletoe leaves extract was administered once a day for 14 days. Then, the IL-2 levels of the mice were checked from their heart blood samples using Enzyme-Linked Immunosorbent Assay, while the percentages of CD4+CD28+ and CD8+CD28+ were examined from the spleen samples using flow cytometry.
RESULTS: The ethanol extract of mango mistletoe leaves was able to increase the percentage of CD4+CD28+ significantly (p < 0.05) at doses of 300 and 600 mg/kg and increase the percentage of CD8+CD28+ significantly (p < 0.05) at a dose of 600 mg/kgBW, while other various doses had a strong enough correlation (r = 0.48) to increase IL-2 levels.
CONCLUSION: The ethanol extract of mango mistletoe leaves has the good potential to inhibit the aging process in the immune system, as characterized by an increase in IL-2 levels and the percentage of CD4+CD28+ and CD8+CD28+.
Kecemasan pada masa kehamilan merupakan perubahan psikologis disebabkan yang disebabkan oleh perubahan hormon kehamilan yang bila tidak ditangani sejak dini dapat berdampak pada kondisi ibu dan janin. Pemberian prenatal yoga dan inhalasi lavender merupakan salah satu terapi non-farmakologi yang efektif dalam meredakan kecemasan dalam masa kehamilan. Tujuan dari penelitian ini yaitu untuk menganalisa pengaruh kombinasi Prenatal Yoga dan inhalasi aromaterapi Lavender terhadap kecemasan pada ibu hamil trimester III di wilayah kerja Puskesmas I Denpasar Timur. Desain yang digunakan adalah Pretest-Posttest Control Group design. Jumlah sampel yang digunakan dalam penelitian ini adalah 30 responden dengan kriteria ; ibu hamil normal TM III tanpa riwayat komplikasi, memiliki keluhan ketidaknyamanan seperti cemas dan bersedia menjadi responden. Pengukuran tingkat kecemasan dapat menggunakan berbagai skala penelitian, salah satunya adalah Hamilton Rating Scale For Anxiety (HARS), serta analisa dilakukan secaa univariatuntuk mengetahui data distribusi dan frekuensi serta analisa bivariat dengan menggunakan uji mann-whitney. Berdasarkan hasil penelitian pada kelompok kontrol menunjukkan tidak ada pengaruh kombinasi Prenatal yoga dan inhalasi aromaterapi lavender terhadap tingkat kecemasan. Analisa kelompok perlakuan menyatakan ada pengaruh kombinasi prenatal yoga dan inhalasi aromaterapi lavender terhadap tingkat kecemasan. Berdasarkan analisa data dengan menggunakan mann whitney diperoleh p value0,000 dimana p value < 0,005 yang berarti bahwa ada pengaruh kombinasi prenatal yoga dan inhalasi aromaterapi lavender terhadap tingkat kecemasan Ibu Hamil TM III. Adanya hasil penelitian ini diharapkan dapat menjadi masukan bagi petugas kesehatan dalam memberikan asuhan kebidanan berbasis nonfarmakologi dalam mengurangi ketidaknyamanan yang dialami selama masa kehamilan.
Introduction: One of the non-pharmacological methods used to increase breast milk production is known as complementary care, one of which is by giving oxytocin massage using lavender aromatherapy oil. The purpose of this study was to determine the effect of oxytocin massage using lavender aromatherapy oil on postpartum mother's milk production.
Methods: This study used a quasi-experimental with pre-test and post-test with a control group. The sample in this study were postpartum mothers with a sample size of 15 respondents in the treatment group and 15 respondents in the control group who met the criteria. The intervention group received oxytocin massage services with lavender aromatherapy oil starting on the 2nd day postpartum, while the control group received breastfeeding assistance, then on the 6th day both groups measured milk production using a Brust Pump. The instrument used is the observation sheet. Hypothesis testing was carried out using the Mann-Whitney test.
Results: Based on the calculation of the Mann-Whitney test, the sig value (p value) is 0.000, where p value <0.05, which means that oxytocin massage using lavender aromatherapy oil has a significant effect on maternal milk production in normal postpartum.
Conclusion: Combination complementary therapy between oxytocin massage and lavender aromatherapy can increase breast milk production in postpartum mothers in Denpasar City.
This community service aims to provide education on how to prevent transmission of Covid-19 transmission for pregnant women in Padangasambian Kaja Village. The method carried out in this service is to provide counseling directly to pregnant women who come to posyandu. Instruments of this activity use leaflets and are analyzed descriptively. The results of this service activity have helped pregnant women to prevent the transmission of Covid-19 during this pandemic, with the help of leaflets about Covid-19 so that the education provided can be applied at home and the surrounding environment.
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