Pityriasis Rubra Pilaris (PRP) is a chronic and rare papulosquamous disorder.
Treatment of Pityriasis Rubra Pilaris is based on empiric evidence because of
several doubts regarding its etiology and also because of its relative rarity,
making randomized studies difficult to perform. Some factors suggest that the
metabolism of vitamin A is involved in pathogenesis. We report a case of
Pityriasis Rubra Pilaris associated with autoimmune hypothyroidism which
presented rapid and complete response after thyroid hormone replacement, without
any association with other systemic treatment. In literature there are only
three other reports of significant improvement of the lesions after hormonal
correction. Deficiency of thyroid hormone inhibits the conversion of carotene
into vitamin A, which would be responsible for the occurrence of Pityriasis
Rubra Pilaris in this patient.
Hansen's disease is a chronic infecto-contagious disease caused by Mycobacterium
leprae. The bacillus prefers low-temperature areas and the nose is usually the
initial site of lesions. Transmission of the bacilli occurs by nasal and
oropharyngeal secretions, and through solutions of continuity of the skin and/or
mucosae. Nasal manifestations are found in the later stages of the disease.
Calcinose cutânea é a precipitação de cristais de cálcio na pele. Pode ser dividida em quatro categorias: distrófica, metastática, iatrogênica e idiopática. A forma distrófica é a mais comum, com níveis séricos normais de cálcio e de fósforo. Relatamos caso de calcinose cutânea distrófica localizada e assintomática no joelho direito de um adolescente. Os exames clínico e laboratorias revelaram telangectasias periungueais e fator antinuclear positivo (títulomaior que 1/1280 de padrão nucleolar), o que sugere a associação da calcinose cutânea com uma colagenose
A sarcoidose é uma doença sistêmica crônica idiopática caracterizada histologicamente por um acúmulo de fagócitos mononucleares e células gigantes, que levam à formação de granulomas não-caseosos em diversos órgãos. O envolvimento cutâneo ocorre, em aproximadamente, 25% dos casos, sendo representado por lesões específicas e não-específicas. Apresentamos caso raro de sarcoidose com lesões cutâneas papulosas e umbilicadas e envolvimento pulmonar.
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