Preparation of 2,3-dihydro-1,3,2-benzoxazaphosphorin-4-one derivatives and their 2-oxo derivatives is described. Compounds 1 and 12 have anticancer activity.
The synthesis of 3-substituted 2-phenyl-2,3-dihydro-4H-1,3,2-benzoxazaphosphorin-4-one 2-sulfide derivatives is described. The action of a series 2-oxide (1-6) and 2-sulfide (7-12) derivatives on the central nervous system has been evaluated. Compounds 1-4, 6, 7-10 exhibit neuroleptic activity. Derivatives of sulfide series act as antiserotoninergic drugs.
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1997 organo-phosphorus compounds, nonmetal heterocycles organo-phosphorus compounds, nonmetal heterocycles S 0087
-191Synthesis and Action on the Central Nervous System of 3-Substituted 2-Phenyl-2,3-dihydro-4H-1,3,2-benzoxazaphosphorin-4-one 2-Oxide and 2-Sulfide Derivatives.-The action of a series of earlier described benzoxazaphosphorinone 2-oxide (IV) and new 2-sulfide (III) derivatives on the central nervous system has been evaluated. The majority of these compounds exhibit neuroleptic activity. Moreover, sulfide derivatives act as antiserotoninergic drugs. -(KOSTKA, K.; PORADA, M.; ZYNER, E.; PAKULSKA, W.; SZADOWSKA, A.; Arch.
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