carried out most of his research at the Karlsruhe Institute of Technology (then, Technische Hochschule Karlsruhe), even after his retirementin1969 until his death on November 7, 1975. The renewed tremendous interest in ozone-organic chemistry is credited to R. Criegee, because of his pioneeringprecise investigations into the mechanism of the ozonolysis reaction. [6] Among Criegee's prolific scientific works, one of his great scientific achievements was the elucidation of the reaction mechanism of the ozonolysis of double bonds, [7] which has contributed enormouslyi ndifferent aspects to the progress of ozonation in organic chemistry. [8,9]

Herein we report the development of a sequential synthesis route towards annulated imidazo[4,5 c]isoquinolines comprising a GBB 3CR, followed by an intramolecular imidoylative cyclisation X-Ray crystallography revealed a flat 3D...

The Groebke–Blackburn–Bienaymé three‐component reaction (GBB‐3CR) has contributed enormously to the progress of organic synthesis, medicinal chemistry, and materials science. Diversity‐oriented synthesis of skeletally diverse cyclophanyl‐derived fused imidazo[1,2‐a]heterocycles by one‐pot GBB‐3CR involving formyl‐cyclophane components in combination with various aliphatic and aromatic isocyanides and heteroaromatic amidines gives a library of versatile cyclophanyl imidazoles ligands. These can be readily transformed to prepare N,C palladacycles by regioselective ortho‐palladation. More information can be found in the Full Paper by S. Bräse et al. (DOI: 10.1002/chem.202103511).

This report describes the synthesis of a [2.2]paracyclophane-derived annulated 3-amino-imidazole ligand library through a Groebke-Blackburn-Bienaymé threecomponent reaction (GBB-3CR) approach employing formylcyclophanes in combination with diverse aliphatic and aromatic isocyanides and heteroaromatic amidines. The GBB-3CR process gives access to skeletally-diverse cyclophanyl imidazole ligands, namely 3-amino-imidazo[1,2-a]pyridines and imidazo[1,2-a]pyrazines. Additionally, a one-pot protocol [a

zu finden. 2020 Die Autoren. AngewandteChemie verçffentlichtv on Wiley-VCH GmbH. Dieser Open Access Beitrag steht unter den Bedingungen der Creative Commons Attribution Non-Commercial License, die eine Nutzung, Verbreitung und Vervielfältigung in allen Medien gestattet, sofern der ursprünglicheBeitrag ordnungsgemäß zitiert und nicht fürkommerzielle Zwecke genutzt wird.[*] Rudolf Criegee , Professorund Direktor des Instituts für Organische Chemie, forschte überwiegend am Karlsruher Institut für Technologie (damals Technische Hochschule Karlsruhe). Auch nach seiner Emeritierung im Jahr 1969 bis zu seinem Todam7.November 1975 galt seine Aufmerksamkeit der Forschung. Die Wiederbelebung des enormen Interesses an der Ozonchemiewird R. Criegee aufgrund seiner bahnbrechenden, präzisen Untersuchungen zum Mechanismusd er Ozonolyse zugeschrieben. [6] Unter Criegees produktiver wissenschaftlicher Arbeit war eine seiner großen Leistungen die Aufklärung des Reaktionsmechanismus fürdie Ozonolyse von Doppelbindungen, [7] die in verschiedener Hinsicht enorm zu ihrem Fortschritt in der organischen Chemie beigetragen hat. [8,9]

Fuel cells used for transport applications hold polymer membranes as a key element. Their efficiency can be significantly increased if structured ion channels are implemented at the molecular level into the proton‐conducting membrane. New functional molecules with selective affinity for ionomers are needed to obtain such a membrane design. This study presents a method to screen for selective peptide binders to perfluorinated sulfonic acid ionomers, e.g., Nafion using ultra‐high density peptide arrays with a spot size of up to 30 µm. First, the ionomer dispersion is incubated with the peptide chip containing 56014 randomly chosen 6‐mer peptides. Afterward, the peptide chip is washed. The peptide WIWHCW with the helix structure is identified as a selective binder to Nafion. The invariant amino acids responsible for binding are also determined using a peptide chip approach. The specific binding pocket of WIWHCW is formed by histidine and tryptophan. Its dissociation constant to the ionomer is measured at ≈140 µM.

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