carried out most of his research at the Karlsruhe Institute of Technology (then, Technische Hochschule Karlsruhe), even after his retirementin1969 until his death on November 7, 1975. The renewed tremendous interest in ozone-organic chemistry is credited to R. Criegee, because of his pioneeringprecise investigations into the mechanism of the ozonolysis reaction. [6] Among Criegee's prolific scientific works, one of his great scientific achievements was the elucidation of the reaction mechanism of the ozonolysis of double bonds, [7] which has contributed enormouslyi ndifferent aspects to the progress of ozonation in organic chemistry. [8,9]

Herein we report the development of a sequential synthesis route towards annulated imidazo[4,5 c]isoquinolines comprising a GBB 3CR, followed by an intramolecular imidoylative cyclisation X-Ray crystallography revealed a flat 3D...

The Groebke–Blackburn–Bienaymé three‐component reaction (GBB‐3CR) has contributed enormously to the progress of organic synthesis, medicinal chemistry, and materials science. Diversity‐oriented synthesis of skeletally diverse cyclophanyl‐derived fused imidazo[1,2‐a]heterocycles by one‐pot GBB‐3CR involving formyl‐cyclophane components in combination with various aliphatic and aromatic isocyanides and heteroaromatic amidines gives a library of versatile cyclophanyl imidazoles ligands. These can be readily transformed to prepare N,C palladacycles by regioselective ortho‐palladation. More information can be found in the Full Paper by S. Bräse et al. (DOI: 10.1002/chem.202103511).

This report describes the synthesis of a [2.2]paracyclophane-derived annulated 3-amino-imidazole ligand library through a Groebke-Blackburn-Bienaymé threecomponent reaction (GBB-3CR) approach employing formylcyclophanes in combination with diverse aliphatic and aromatic isocyanides and heteroaromatic amidines. The GBB-3CR process gives access to skeletally-diverse cyclophanyl imidazole ligands, namely 3-amino-imidazo[1,2-a]pyridines and imidazo[1,2-a]pyrazines. Additionally, a one-pot protocol [a

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