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Depressive symptoms are associated with cognitive-functional impairment in normal aging older adults (NA). However, less is known about this effect on people with mild Cognitive Impairment (MCI) and mild Alzheimer's disease dementia (AD). We investigated this relationship along with the NA-MCI-AD continuum by reanalyzing a previously published dataset. Participants (N = 274) underwent comprehensive neuropsychological assessment including measures of Executive Function, Language/Semantic Memory, Episodic Memory, Visuospatial Abilities, Activities of Daily Living (ADL), and the Geriatric Depression Scale. MANOVA, logistic regression and chi-square tests were performed to assess the association between depression and cognitive-functional performance in each group. In the NA group, depressed participants had a lower performance compared to non-depressed participants in all cognitive and functional domains. However, the same pattern was not observed in the MCI group or in AD. The results suggest a progressive loss of association between depression and worse cognitive-functional performance along the NA-MCI-AD continuum.

Introduction: The increase in life expectancy is a global reality and determines the highest prevalence of chronic diseases and greater demand for health services, including hospitals. Currently, studies have focused on functional decline and its consequences -the demand for material and human resources, institutionalization and hospitalization. This paper aimed to critically review the available literature on the risk factors associated with functional decline in hospitalized elderly people. Methodology: Search the databases MEDLINE, LILACS and SciELO, in English and Portuguese between 2000 and 2007, using the key words hospital, elderly, functional status, aged and functional decline and references of selected articles.

The use of alternative feeding, along with the number of pressure ulcers were associated with an increased risk of death in elderly patients with advanced dementia. A higher incidence of aspiration pneumonia was also observed in the alternative feeding group. The number of hospital admissions was not different between the feeding routes.

The antioxidant vitamin complex was effective in reducing oxidative stress in PBMNC of AD patients by lowering ROS production, improving cellular antioxidant capacities and modifying cytokine induced inflammation.

No abstract

Latencies of N200 and P300 increased in cognitively impaired patients with the presence of ApoE ε-4 allele.

INTRODUÇÃO: tontura é queixa freqüente na população geriátrica e interfere na qualidade de vida desses indivíduos. OBJETIVO: descrever as causas de tontura, correlacionar sintomas e alterações na prova calórica e verificar o impacto da presbivertigem como fator primário de tontura em população de idosos. MÉTODO: revisão do prontuário de 132 pacientes com mais de 60 anos e distúrbio do equilíbrio corporal, atendidos no ambulatório de Otoneurologia do Hospital das Clínicas da UFMG, no período de 1998 a 2007. As variáveis analisadas foram: dados epidemiológicos, história clínica, doenças associadas e resultado da prova calórica. Casos de vertigem de posição e suspeita de lesão central foram excluídos da análise. RESULTADOS: A amostra constou de 120 pacientes. A idade média foi de 70 anos, sendo 87 (71%) mulheres. Dentre os tipos de tontura, vertigem de alguns minutos de duração e freqüência diária foi mais freqüente. Em relação ao resultado da prova calórica, exame normal foi observado em 73% e, dentre os resultados alterados, hiporreflexia bilateral (presbivertigem) foi observada em 8%. Correlacionando-se com o tipo de tontura, hiporreflexia bilateral associou-se com instabilidade postural (p = 0,006; IC = 2 - 419). CONCLUSÃO: tontura no idoso tem causa multifatorial. Perda da função vestibular periférica pode estar relacionada à presbivertigem e deve ser considerada em pessoas idosas com desequilíbrio. Distúrbios metabólicos, psíquicos, disautonômicos, ortopédicos, visuais e de propriocepção podem ser causa de tontura em idosos com exame vestibular normal.