Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer in the world, with 890 000 new cases and 450 000 deaths in 2018 worldwide. 1 Despite improvements in research and therapy made in the last decades, survival has not significantly improved and the 5 years overall survival (OS) rate is still less than 50%. 2 Classic prognostic factors are not sufficient to predict patients' prognosis, due to the heterogeneity of molecular mechanisms and tumour behaviours related to HNSCC. For these reasons, there has been an intensified interest in biomarkers' discovery for early diagnosis, prognosis and personalized treatment.In this scenario, inflammatory biomarkers became a reliable and accessible source of information to investigate and correlate to
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