Pre‐treatment neutrophil‐to‐lymphocyte ratio is an independent prognostic factor in head and neck squamous cell carcinoma: Meta‐analysis and trial sequential analysis

Mariani, Pierluigi; Russo, Diana; Maisto, Marco; Troiano, Giuseppe; Caponio, Vito Carlo Alberto; Annunziata, Marco; Laino, Luigi

doi:10.1111/jop.13264

Cited by 31 publications

(32 citation statements)

References 89 publications

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“…In addition, high fibrinogen and high NLR were found to be important indicators for predicting clinical outcome in this study ( P < 0.001 and P = 0.008). The results of our study are consistent with those of previous meta-analyses, showing that high NLR significantly reduces the survival time of head and neck squamous cell carcinoma patients [ 28 ]. We propose the following mechanism of action: Fibrinogen may function by forming a protective framework that facilitates tumor migration, invasion, and angiogenesis.…”

Section: Discussionsupporting

confidence: 92%

“…Alternatively, NLR could be used as an independent prognostic indicator in patients with OSCC [ 27 ]. A recent meta-analysis of 17 studies with 4597 patients showed that pre-treatment NLR correlates with a statistically significant decrease of OS in head and neck squamous cell carcinoma patients [ 28 ]. The generation of inflammatory cytokines/chemokines by neutrophils facilitates the occurrence and development of tumors by creating a suitable tumor microenvironment [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

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Prognostic role of an inflammation scoring system in radical resection of oral squamous cell carcinoma

Zhang

et al. 2022

BMC Oral Health

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Background Inflammatory markers can influence the postoperative prognosis and outcome of malignant tumors. However, the role of inflammatory factors in oral squamous cell carcinoma (OSCC) are still debatable. The primary objective of this investigation was to detect the preoperative blood fibrinogen and neutrophil–lymphocyte ratio (NLR) in OSCC patients and to determine the predictive validity of F-NLR (combined fibrinogen and NLR score). Methods A total of 365 patients with oral cancer after surgery were separated into three classes: F-NLR of 2, with hyperfibrinogenemia (> 250 mg/dL) and high NLR (> 3.2); F-NLR of 1, with only one higher index; and F-NLR of 0, with no higher indices. Univariate and multivariate analyses were used to identify risk factors for the demographic and clinical characteristics of patients in the three F-NLR groups. Kaplan–Meier survival analysis was used to assess the prognosis. Results Preoperative F-NLR showed a relatively better predictive role in oral cancer prognosis than fibrinogen and NLR alone. Multivariate analysis revealed that F-NLR has the potential to be an independent predictor for OSCC cancer-specific survival (P < 0.001). Patients with high scores had a relatively poorer prognosis than those with low scores (P < 0.001). Conclusions Our findings indicate that blood F-NLR may serve as an independent prognostic factor in OSCC patients.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Prognostic role of an inflammation scoring system in radical resection of oral squamous cell carcinoma

Zhang

et al. 2022

BMC Oral Health

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“…In particular, the over-regulation of miR-21 [ 7 , 8 ], miR-155 [ 9 ], and miR-31 [ 10 ] would be associated with a worse prognosis, and among the downregulated is reported miR-195 [ 11 ]. Confirmation of these data also comes from recent systematic reviews with meta-analysis, conducted on the prognostic value of these groups of microRNAs [ 12 ]. In a similar way, more miRs are associated with a possible use as a prognostic biomarker of survival in HNSCC, and among these were recently highlighted the miR-196a and the miR-196b [ 13 ].…”

Section: Introductionmentioning

confidence: 64%

Potential Role of miR-196a and miR-196b as Prognostic Biomarkers of Survival in Head and Neck Squamous Cell Carcinoma: A Systematic Review, Meta-Analysis and Trial Sequential Analysis

Dioguardi

Cantore²,

Sovereto

et al. 2022

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The etiopathogenetic mechanisms involving tumor genesis, including alteration of cell proliferation, apoptosis, invasion, migration, and death, may lead to alterations in microRNAs (miR) expression. The hypothesis is that with the presence in the literature of recent studies conducted on miR-196a and miR-196b, it is possible to clearly determine, by aggregating the results, whether miR-196 upregulation in head and neck squamous cell carcinoma (HNSCC) tissues can represent a prognostic biomarker of survival through hazard ratio (HR) analysis. The systematic review was conducted following the indications of the PRISMA, and four electronic databases were used (Science Direct, SCOPUS, PubMed, and Cochrane Central), with the addition of gray literature. Combinations of keywords were used, such as miR-196, miR-196 AND HNSCC, microRNA AND HNSCC, LSCC AND miR-196, OSCC AND miR-196, OPSCC AND miR-196, HSCC AND miR-196. The meta-analysis and test sequential analysis were performed using RevMan 5.41 software and Stata 13 (StataCorp, College Station, TX, USA) with the implementation of the R 4.2 software. This search identified 1593 reports and, at the end of the selection, five articles were inserted. The results of the meta-analysis report an aggregate HR for overall survival (OS), between the highest and lowest miR-196 expression of 1.67, 95% CI: [1.16, 2.49]. In this meta-analysis, we found that the forest plot is in favor of higher OS in HNSCC patients, compared with the control, with low miR-196 expression, correlating this data with a favorable prognosis, which indicated the potential role of this miRNA in strengthening the therapy sensitiveness of the HNSCC patients. Consequently, the present systematic review places itself, together with other systematic reviews on this topic, in a key role to the finding of Phase 3 clinical trials studies, in search for a prognostic model of miR-196 for HNSCC. In conclusion, with the limitations of the systematic review, it can be argued that miRs of the miR-196 family could be independent prognostic biomarkers of survival for HNSCC.

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“…The idea of to diagnose cancer through simple routine laboratory tests with a little amount of blood samples is worthy of investigation for many researchers. Some inflammatory markers including lymphocyte to monocyte ratio, neutrophil to lymphocyte ratio, albumin to globulin ratio were described previously , however, majority of these studies aimed to evaluate only the prognostic significant of the aforementioned markers in different cancer types (Stotz et al, 2014;Jia et al, 2015;Gu et al, 2016;Hsueh et al, 2017;Tan et al, 2018;Song et al, 2021;Tezuka et al, 2021;Atsumi et al, 2021;Castineiras et al, 2021;Mariani et al, 2022). There were a only a few studies had been published about association between systemic inflammatory markers and prediction of cancer diagnosis (Kocer et al, 2015;Li et al, 2017;Ataş et al, 2021) .…”

Section: Discussionmentioning

confidence: 99%

The Role of Inflammatory Markers and the Modified Systemic Inflammatory Score in Bethesda Category 3 And 4 Patients for Prediction of Malignancy

OCAK

BÜK

SARI

et al. 2022

Black Sea Journal of Health Science

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Background: Management of Bethesda Category 3 and 4 patients remains a challange. The modified systemic inflammatory score (mSIS) and other inflammatory parameters are used for prognosis assesment in various cancers. This retrospective study aims to explore prediction strength of the inflammatory parameters in Category 3 and 4 patients Methods: One hundred and twenty three patients had undergone thyroidectomy for Category 3 and 4 fine needle aspiration biopsy (FNAB). The data of inflammatory markers including Neutrophil to lymphocyte ratio (NLR), lymphocyte to monocyte ratio (LMR) ,albumin to globulin ratio (AGR) and mSIS were evaluated retrospectively. Results: There were no statistically significant difference in inflammatory parameters between benign and malignant patients and none of the inflammatory parameters had predictivity for thyroid cancer. Also in mSIS groups, thyroid cancer incidence were similar (p=0.684) Conclusion: Inflammatory parameters and mSIS were failed to predict thyroid cancer in patients who had category 3 and 4 FNAB.

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Pre‐treatment neutrophil‐to‐lymphocyte ratio is an independent prognostic factor in head and neck squamous cell carcinoma: Meta‐analysis and trial sequential analysis

Cited by 31 publications

References 89 publications

Prognostic role of an inflammation scoring system in radical resection of oral squamous cell carcinoma

Prognostic role of an inflammation scoring system in radical resection of oral squamous cell carcinoma

Potential Role of miR-196a and miR-196b as Prognostic Biomarkers of Survival in Head and Neck Squamous Cell Carcinoma: A Systematic Review, Meta-Analysis and Trial Sequential Analysis

The Role of Inflammatory Markers and the Modified Systemic Inflammatory Score in Bethesda Category 3 And 4 Patients for Prediction of Malignancy

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