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Using numerical simulations we show how to realise an optical black hole laser, i.e. an amplifier formed by travelling refractive index perturbations arranged so as to trap light between a white and a black hole horizon. The simulations highlight the main features of these lasers: the growth inside the cavity of positive and negative frequency modes accompanied by a weaker emission of modes that occurs in periodic bursts corresponding to the cavity round trips of the trapped modes. We then highlight a new regime in which the trapped mode spectra broaden until the zero-frequency points on the dispersion curve are reached. Amplification at the horizon is highest for zero-frequencies, therefore leading to a strong modification of the structure of the trapped light. For sufficiently long propagation times, lasing ensues only at the zerofrequency modes.

We generate nonclassical conditional states by exploiting the quantum correlations of multi-mode twin-beam states endowed with a sizeable number of photons. A strong relation between the subshot-noise correlations exhibited by twin beams and the sub-Poissonian character of the conditional states is experimentally revealed. It determines optimal conditions for sub-Poissonian light generation.

We present a robust tool to analyze nonclassical properties of multimode twin-beam states in the mesoscopic photon-number domain. The measurements are performed by direct detection. The analysis exploits three different non-classicality criteria for detected photons exhibiting complementary behavior in the explored intensity regime. Joint signal-idler photon-number distributions and quasi-distributions of integrated intensities are determined and compared with the corresponding distributions of detected photons. Experimental conditions optimal for nonclassical properties of twin-beam states are identified.

This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Highlights  The  1 band of N 2 O is measured with an extended-cavity quantum cascade laser near 7.8 m  The spectrometer is frequency locked to a Tm:based frequency comb at 1.9 m  70 lines are measured with an estimated systematic uncertainty of 60 kHz.  Accurate spectroscopic constants of the 10 0 0 upper state are derived  The rms of the fit of the line centers is ≈ 4.8×10-6 cm-1 (144 kHz)

Cytosine methylation is a widespread epigenetic regulation mechanism. In healthy mature cells, methylation occurs at CpG dinucleotides within promoters, where it primarily silences gene expression by modifying the binding affinity of transcription factors to the promoters. Conversely, a recent study showed that in stem cells and cancer cell precursors, methylation also occurs at non-CpG pairs and involves introns and even gene bodies. The epigenetic role of such methylations and the molecular mechanisms by which they induce gene regulation remain elusive. The topology of both physiological and aberrant non-CpG methylation patterns still has to be detailed and could be revealed by using the differential stability of the duplexes formed between site-specific oligonucleotide probes and the corresponding methylated regions of genomic DNA. Here, we present a systematic study of the thermal stability of a DNA oligonucleotide sequence as a function of the number and position of non-CpG methylation sites. The melting temperatures were determined by monitoring the fluorescence of donor-acceptor dual-labelled oligonucleotides at various temperatures. An empirical model that estimates the methylation-induced variations in the standard values of hybridization entropy and enthalpy was developed.

Abstract:It is shown that spatial correlation functions measured for correlated photon pairs at the single-photon level correspond to speckle patterns visible at high intensities. This correspondence is observed for the first time in one experimental setup by using different acquisition modes of an intensified CCD camera in low and high intensity regimes. The behavior of intensity auto-and cross-correlation functions in dependence on pumpbeam parameters including power and transverse profile is investigated. Lett. 93, 243601 (2004). 16. G. Brida, M. Genovese, A. Meda, E. Predazzi, and I. Ruo Berchera, "Systematic study of the PDC speckle structure for quantum imaging applications," Int.

We report for the first time the frequency locking of an extended-cavity quantum-cascade-laser (EC-QCL) to a near-infrared frequency comb. The locked laser source is exploited to carry out molecular spectroscopy around 7.8 μm with a line-centre frequency combined uncertainty of ~63 kHz. The strength of the approach, in view of an accurate retrieval of line centre frequencies over a spectral range as large as 100 cm−1, is demonstrated on the P(40), P(18) and R(31) lines of the fundamental rovibrational band of N2O covering the centre and edges of the P and R branches. The spectrometer has the potential to be straightforwardly extended to other spectral ranges, till 12 μm, which is the current wavelength limit for commercial cw EC-QCLs.