No abstract

Background:The immunodetection of VEGF, ANG-1 and 2 was investigated in oral lichen planus (OLP) and in control groups to compare angiogenesis between lesions with different degrees of aggressiveness. Methods:A cross-sectional observational study was performed in 21 reticular (ROLP) and 11 atrophicerosive (AEOLP) specimens of OLP and in 10 cases of oral fibroepithelial hyperplasia (OFH), oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC). Results:The results do not revealed significant difference in the immunodetection of ANG-1 and ANG-2 between OLP groups. The ROLP group showed significantly greater immunodetection of VEGF compared with the EOLP group. The comparison between the OLP group and each control group showed significantly greater levels of ANG-1 in the OLP group compared to the OFH group and no significant difference in ANG-2. VEGF levels in the OLP group were significantly higher than in the OFH group and significantly lower compared to the OSCC group. Conclusion:In this small sample, the results indicate that angiogenesis in OLP cannot be associated to the different clinical forms of this disease. The lack of correlation between the markers in the OLP groups suggests the involvement of other pro-angiogenic agents and reflect the complexity this process and the necessity for further studies. Immunodetection of these growth factors in the OLP and OED groups was similar, demonstrating that angiogenesis in OLP may behave similarly to OED.

The tumor presents an irregular growth. Smaller islands are associated with a higher proliferation activity and therefore could be responsible for tumor infiltration.

Com o objetivo de obter um perfil de indivíduos afetados por ameloblastoma e comparar os resultados com os estudos encontrados na literatura, realizou-se uma análise retrospectiva dos casos de ameloblastomas do Laboratório de Patologia Bucal da FO-UFRGS. Os resultados revelaram uma maior ocorrência em indivíduos jovens, do sexo feminino, raça branca, localização predominantemente na mandíbula e tipo histológico plexiforme. Conclui-se que, o perfil dos pacientes com ameloblastoma diagnosticados no Laboratório de Patologia Bucal da FO-UFRGS concorda com o perfil de pacientes com ameloblastoma diagnosticado em outras partes do mundo e relatado na literatura, diferindo apenas no que se refere a faixa etária no momento do diagnóstico.

Triple X syndrome (47,XXX) is a numerical chromosomal alteration that affects 1/1,000 women, in which the woman is born with an extra X chromosome. Some oral changes have been reported in the literature, as hypodontia, influence on deposition of crown enamel and discrepancies in cephalometric measurements. Other systemic complications may lead to oral abnormalities similar to those seen in triple X patients, such as congenital hypothyroidism (CH). This paper reports a triple X syndrome case associated with CH later treated. Besides delay in cognitive and intellectual development, the patient had changes in teeth development and in cephalometric measurements with deficiencies in the maxilla and mandible. This is the first report of a triple X syndrome associated with CH. Both conditions may result in changes in dentofacial development.