Angiogenesis in Oral Lichen Planus: A Comparative Study with Lesions of Different Degrees of Aggressiveness

Cherubini, Karen; Silva, Vinícius Duval da; Lopes, Tiago Giuliani; Figueiredo, Maria Antonia Zancanaro de; Salum, Fernanda Gonçalves; Payeras, Márcia Rodrigues

doi:10.31031/mrd.2019.04.000578

Cited by 2 publications

(21 citation statements)

References 25 publications

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“…Data regarding the quantitative assessment of angiogenesis from 21 studies 13–16,18,19,21–25,29–37,40 has been elaborated in Table S3. Thirteen 13,14,16,19,21,23,31–36,40 assessed the angiogenic status by calculating the microvessel density (MVD).…”

Section: Resultsmentioning

confidence: 99%

“…Twelve out of thirteen studies mentioned about the method of measurement out of which seven calculated MVD in 5 hotspot areas at 20× magnification, while the remaining five chose 40× with 3, 36 4 16,21,23 and 5 31 hotspot areas for evaluation, respectively. The mean area percent value and positively stained cells were evaluated in six studies 15,22,24,25,29,35 using VEGF, VEGFR2, Vasohibin, CD34, ALK1, ANG‐1, and ANG‐2 markers. Two studies 25,35 assessed 10 (equidistant/successive) fields at 20× magnification while another four employed various microvascular compartments, 22 five 22,24 hotspots and three 29 random fields at 20× and 40× magnification, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…Increased angiogenesis has since long been assessed and linked to its pathogenesis, chronicity, progression, clinical activity and malignant conversion 14–20 . Although, many investigators depict a non‐significant relationship between angiogenesis and OLP, others claim the importance of angiogenic modulators in it 20–25 . Furthermore, undefined mechanisms and ambiguity with respect to the role of angiogenesis in OLP limit the use of an anti‐angiogenic drug in targeted therapy.…”

Section: Introductionmentioning

confidence: 99%

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An exotic pathogenetic mechanism of angiogenesis in oral lichen planus—A systematic review

Keerthika

Kamboj

Girdhar

et al. 2023

J Oral Pathology Medicine

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ObjectiveAngiogenesis plays a vital role at the molecular level in various inflammatory lesions, that lead to their chronicity. Oral lichen planus is an immune‐mediated chronic inflammatory disorder. The angiogenetic role and exact mechanisms in oral lichen planus are still unclear due to a dearth of studies. Its clinical significance with angiogenesis also requires further elucidation necessitating a thorough review of the studies that have been conducted so far. The present review was designed to identify the dependence of oral lichen planus progression on angiogenesis which could aid in devising metronomic treatments required to halt the progression of this disease.Materials and MethodsA thorough search was made using MEDLINE by PubMed, Scopus, Google scholar, Cochrane library, and EMBASE databases. Original research articles, that immunohistochemically evaluated angiogenesis in oral lichen planus were included for review. Risk of bias was analysed for each study using Modified Newcastle‐Ottawa scale and Review Manager 5.4 was used to output its result.ResultsTwenty‐nine published articles were included for data synthesis. The most commonly employed antibody was CD34, however, upregulated VEGF expression was the principal while ICAM‐1, VCAM‐1, and PECAM‐1 were critical angiogenic factors to mediate angiogenesis in oral lichen planus.ConclusionThe current evidence supports that angiogenesis, a fundamental pathogenetic mechanism of oral lichen planus, leads to its persistence and chronicity. However, studies with a larger sample size, standard evaluation criteria, different subtypes, and adequate follow‐up are warranted.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

An exotic pathogenetic mechanism of angiogenesis in oral lichen planus—A systematic review

Keerthika

Kamboj

Girdhar

et al. 2023

J Oral Pathology Medicine

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“…Payers et al 7 recently investigated immunodetection of ANG‐1, ANG‐2, and VEGF as well as the blood vessel number in samples in samples from patients with OLP and other; immunodetection of ANG‐2 was not significantly different among samples of OLP (divided into specimens from patients with reticular, atrophic, or erosive OLP), oral fibroepithelial hyperplasia, oral epithelial dysplasia, and oral squamous cell carcinoma. They found that the angiogenesis factors were similarly immunodetected in both the OLP and oral epithelial dysplasia groups, demonstrating that OLP angiogenesis may act similar to that of oral epithelial dysplasia.…”

Section: Discussionmentioning

confidence: 99%

“… 4,5 Studies have investigated the angiogenesis process in OLP, which is characterized by rich vascularization that is probably due to hypoxia from lymphocyte's proliferation 6 . Recent studies showed an increase in VEGF expression and in micro‐vessel density in OLP, particularly in the erosive type, suggesting that angiogenesis can play a distinct role in the different clinical presentations of lichen disease 7 …”

Section: Introductionmentioning

confidence: 99%

Serum angiopoietin‐2 level as a novel potential biomarker in oral lichen planus

Bessar

Hammad

Ismail

et al. 2021

J of Cosmetic Dermatology

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Background Lichen planus is a common chronic cutaneous inflammatory disease. Recent advances evidenced that angiogenesis is tightly connected to it. More recently, the endothelial specific growth factor angiopoietin‐2 has been clarified to interact with vascular endothelial growth factor. Angiopoietin‐2 level has not been investigated in lichen planus. Aim To evaluate serum level of angiopoietin‐2 in cutaneous and oral lichen planus. Methods Ninety patients were investigated, 45 patients with lichen planus. In addition to forty‐five healthy control, the activity of the disease was estimated at the time of examination. The serum level of angiopoietin‐2 had been estimated by enzyme‐linked immunosorbent assay. The relationships between angiopoietin‐2 serum level and disease severity, type of lichen, and visual analogue scale score (VAS) were determined. Results The serum levels of angiopoietin‐2 were substantially higher in patients with both cutaneous and oral lesions than patients with cutaneous lichen planus only (P < .001). Conclusions Serum angiopoietin‐2 is elevated in patients compared with normal subjects and is correlated with the presence of oral lesions and disease severity, that reflects its role in angiogenesis and inflammation, and angiopoietin‐2 serum level could be a potential marker for monitoring the oral lichen to identify possible malignant transformation.

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Angiogenesis in Oral Lichen Planus: A Comparative Study with Lesions of Different Degrees of Aggressiveness

Cited by 2 publications

References 25 publications

An exotic pathogenetic mechanism of angiogenesis in oral lichen planus—A systematic review

An exotic pathogenetic mechanism of angiogenesis in oral lichen planus—A systematic review

Serum angiopoietin‐2 level as a novel potential biomarker in oral lichen planus

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