Este trabalho teve como objetivo analisar o uso de medicamentos administrados por sonda aos pacientes das unidades de terapia intensiva adulto e neonatal de um hospital de ensino. Trata-se de um estudo de caráter descritivo, exploratório e quantitativo, realizado em março/2011 a partir de prescrições oriundas das respectivas unidades, com foco nas recomendações de uso desses medicamentos via sonda. As informações foram coletadas e analisadas no programa Epi Info versão 3.5.2. Analisou-se 572 prescrições, somando 5.283 medicamentos. Dentre os medicamentos com forma farmacêutica de uso oral, a maioria (88,8%) foi prescrita para administração por sonda. Desta, 11 tiveram restrição de uso. A alta frequência de medicamentos prescritos para administração por sonda, aliada aos diferentes tipos de restrições que inviabilizam seu uso por essa via, evidencia a necessidade da implantação de programas de educação continuada, bem como a criação de manuais educativos que busquem aprimorar o conhecimento dos profissionais envolvidos
Cytopathic effects related to the human papillomavirus (HPV) infection are more frequently found in cervical intraepithelial neoplasia (CIN) 1; however, there are indications that at least half the histological diagnoses of CIN2 and CIN3 include koilocytosis areas. The objective of this study was to evaluate the frequency of the cytological criteria suggestive of HPV infection in the cervical smears of women with a histological diagnosis of CIN. One hundred and sixty-two women with abnormal cervical smears and a diagnosis of CIN confirmed by histopathology were selected, including 46 cases of CIN 1, 42 of CIN 2 and 74 cases of CIN 3. Koilocytosis was found in 63% of the smears from women with a histopathological diagnosis of CIN 1. This sign was observed in 26.2% and 25.7% of smears of women with a diagnosis of CIN 2 and CIN 3, respectively. Cytomegaly also was frequent in cervical smears of women with histopathological diagnosis of CIN 1 (71.8%). On the other hand, spindle cells and atypical metaplasia were more frequent in women with CIN 2 and CIN 3. Atypical parakeratosis showed similar frequency in all grades of CIN diagnosis. Koilocytois and cytomegaly were inversely correlated with the diagnosis of CIN2 or CIN 3, with OR values respectively of 0.30 (95%CI 0.13-0.68) and 0.26 (95%CI 0.11-0.58). The others signs analyzed did not show any significant association. Koilocitosis and cytomegaly can provides good reassurance that a patient with atypical cervical smear have CIN 1.
O presente estudo teve como objetivo apresentar os impactos do estágio de Farmácia Hospitalar desenvolvido pela Faculdade de Farmácia da Universidade Federal de Goiás (FF/UFG) no Hospital Veterinário da Escola de Veterinária e Zootecnia da Universidade Federal de Goiás (HV/EVZ/UFG), tanto na formação acadêmica dos estagiários, quanto nos serviços da unidade. Trata-se de um relato de experiência da atuação e das atividades propostas pelos alunos da faculdade de farmácia ao HV/EVZ/UFG, supervisionados pelo farmacêutico da unidade e orientados pelo docente responsável pela disciplina, como forma de avaliação do estágio em farmácia hospitalar. Os principais temas propostos foram relacionados à implementação de ações de esterilização e limpeza, ações de farmacovigilância, sistema de padronização e distribuição de medicamentos. A receptividade na aceitação das propostas apresentadas resultou em impactos positivos ao HV/EVZ/UFG, como a promoção do uso racional de medicamentos, o monitoramento do controle de qualidade e a redução de problemas relacionados a medicamentos. Além disso, possibilitou aos alunos atender aos objetivos da disciplina e ainda obterem experiência com o uso de medicamentos veterinários. Conclui-se portanto que a experiência proporcionou impactos positivos tanto para os alunos da disciplina de farmácia hospitalar da FF/UFG como para o HV/EVZ/UFG.
Objective: We aimed at investigating and describing the drug and material resources in health shortage in the Brazilian services during the COVID-19 pandemic. Methods: We conducted a cross-sectional study in the format of an online survey with closed questions. Information was sought about the institutional and care profile, pharmaceutical service organization, non-compliance in the stock, or lack of drugs and other health products between April and October 2020. We performed descriptive, univariate, and multivariate statistical analyses, such as Fisher's t-test, chi-square test, and the Multiple Correspondence and Hierarchical Cluster analyses. A p-value below 0.05 and a 95% significance level were considered. Results: 228 Brazilian institutions, most located in the capital cities, with specific beds for COVID-19 and public administration, were included in the study. Grouping by similarity separated the study sample into five heterogeneous clusters. Eighty-four percent of the services indicated a drugs shortage, especially neuromuscular blocking agents (64.9%), hypnotics and sedatives (52.9%), vasoactive drugs (37.3%), and antiinfective agents (30%). Conclusion: In all the clusters, there were reports of a shortage of items considered essential in the management of critically-ill patients, corroborating the perception that this was a significant challenge for pharmaceutical assistance in various Brazilian services during the COVID-19 pandemic.
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