No abstract

The synthesis of new 4-(phenylamino)-1-phenyl-1H-pyrazolo [3,4-b]pyridine-4-carboxylic acid (3a-l) derivatives and the new 4-[(methylpyridin-2-yl)amino]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid (5a-c) derivatives was achieved with an efficient synthetic route. Ethyl 4-chloro-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate (1) on fusion with appropriate substituted anilines or aminopicolines gave the required new ethyl 4-(phenylamino)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylates (2a-l) (52-82%) or new ethyl 4-[(methylpyridin-2-yl)amino]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylates (4a-c) (50-60%), respectively. Subsequent hydrolysis of the esters afforded the corresponding carboxylic acids (3a-l) (86-93%) and (5a-c) in high yield (80-93%). Inhibitory effects of 4-(phenylamino)/4-[(methylpyridin-2-yl)amino]-1-phenyl-1H-pyrazolo [3,4-b]pyridine-4-carboxylic acids. Derivatives on Herpes simplex virus type 1 (HSV-1), Mayaro virus (MAY) and vesicular stomatitis virus (VSV) were investigated. Compounds 2d, 3f, 3a, and 3c exhibited antiviral activity against

The Novel Enablers for Cloud Slicing (NECOS) project addresses the limitations of current cloud computing infrastructures to respond to the demand for new services, as presented in two use-cases, that will drive the whole execution of the project. The first use-case is focused on Telco service provider and is oriented towards the adoption of cloud computing in their large networks. The second use-case is targeting the use of edge clouds to support devices with low computation and storage capacity. The envisaged solution is based on a new concept, the Lightweight Slice Defined Cloud (LSDC), as an approach that extends the virtualization to all the resources in the involved networks and data centers and provides uniform management with a high-level of orchestration. In this position paper, we discuss the motivation, objectives, architecture, research challenges (and how to overcome them) and initial efforts for the NECOS project.

No abstract

No abstract

No abstract

No abstract

No abstract