No abstract

Introduction: Repeated overloads of a tendon may give rise to an inflammatory response, called tendinitis, which usually begins suddenly. Researches report that the Brazilian Northeast is common to use the pequi oil (Caryocar Coriaceum wittm) in the treatment of inflammation and other diseases. Objective: To evaluate the anti-inflammatory effect of pequi oil in tendon repair process in rats after induced tendinitis. Methods: 36 male rats were divided into groups: control, ultrasound + oil pequi and pequi oil. To induce tendinitis, it was used a intratendineous injection of collagenase in the right calcaneal tendon. The treatment consisted of daily application of ultrasound + pequi oil or just pequi oil on the tendon. Macroscopic analysis was performed with the pachymeter on 1st, 7th and 14th days. Posteriorly, the rats were sacrificed with an overdose of intravenous barbiturate, then it was dissected and removed the tendon to enable the histological analysis with Hematoxylin & Eosin (HE). Results: There was a reduction in the number of inflammatory cells in the animals treated for 7 days in the groups UST + pequi oil and pequi oil compared to the control, with p <0,001. At 14 days, the group UST + pequi oil showed greater number of fibroblasts than the other groups, with p<0,01. Conclusion: The pequi oil accelerated the tendon repair in the animals and the treatment with US + pequi oil was the most effective because it reached good statistical significance in seven and 14 days.

Introdução: Existem vários estudos sobre a utilização do pequi (Caryocar brasiliense) no processo cicatricial; contudo, em poucos trabalhos desenvolvidos, avaliou-se resistência à tensão pós-tratamento. Objetivo: Analisar a tensão cicatricial em incisões cutâ¬neas de ratos, após terapia com Caryocar brasiliense. Método: Vinte ratos Wistar, divididos em dois grupos (placebo/tratado), sofreram incisão cutânea no dor¬so. O grupo tratado recebeu doses diárias de óleo de Caryocar brasiliense, e o placebo aplicação de óleo mineral. Após sacrifício, em sete e quatorze dias pós-cirurgia, amostras de pele foram submetidas à análise tênsil-histológica. Resultados: Observou-se diferença significante intergrupos na força máxima de tração, assim como uma elevação da síntese de colágeno na área das lesões no grupo tratado com óleo Caryocar brasiliense. Conclusão: A terapia com óleo de Caryocar brasiliense aumenta a resistência tênsil da pele, melhorando a resposta reparacional, reduzindo riscos de deiscência e complicações pós-cirúrgicas.

PURPOSE:To compare the biomodulatory effects of LED and ultrasound combined with semipermeable dressing in the repair of cutaneous lesions. METHODS:Eighty-four Wistar rats were submitted to surgical injury (2.5 cm) and divided into four groups (n=21): Group I (control), Group II (LED therapy, LED), Group III (LED therapy + dressing, LED+D) and Group IV (ultrasound + dressing, US+D). At seven, 14 and 21 days, the animals were euthanized, and the specimens of interest removed for histological analysis. RESULTS:Histological and histomorphometric analysis revealed a greater percent wound regression in animals receiving the dressing (group III: 55.97; group IV: 53.06), as well as a greater reduction in the inflammatory infiltrate (group III: 29.14; group IV: 31.71) since day 7. A later effect, with progression of the tissue repair process only after 14 and 21 days, was observed in the LED group intense fibroblast proliferation and greater collagen fiber production and organization were seen in the LED+D and US+D groups compared to the other groups.CONCLUSION: LED combined with a dressing was more effective at accelerating in the repair of cutaneous lesions.

Introduction: Patients with diabetes mellitus exhibit a delay in the lesion repair process. The active components of Cenostigma macrophyllum may represent a viable alternative to facilitate the recovery of these lesions. The aim of this study was to evaluate the effects of emulsion oil-water Cenostigma macrophyllum in the repair process of lesions in rats with induced diabetes. Methods: 63 male rats (Wistar, 200-250 g body weight, 30-40 days old) were distributed into the following groups: control (C), diabetic (D) and diabetic treated with Cenostigma macrophyllum (P), subdivided based on the experimental times, days 7, 14 and 28, with 21 animals per main group. Diabetes mellitus (DM) was induced by administration of streptozotocin (50 mg/kg via penile vein and 12-h fasting) and confirmed at day 21 (glycemic index > 240 mg/dL). In the animals of group P, 0.5 ml of the oil-water emulsion obtained from the plant seed was used. The samples were removed and hemisectioned, and one portion was used for the quantitative histological analysis of collagen using Masson's trichrome staining, while another portion was analyzed by FT-Raman spectroscopy. Results: A higher percentage area of the volume of collagen fibers was observed for the experimental time Day 14 in group P compared with group D (p < 0.001). Regarding the ratio of areas of the amides I (1700-1600 cm -1 ) and III (1245-1345 cm -1 ), the groups D and P show the opposite behavior. Conclusion: Cenostigma macrophyllum accelerated the repair process in skin of diabetic ratsfor14 days.

No abstract

The objective of this study was to verify the possible association between Glutathione Stransferase genetic polymorphism and functional physical aspects in the elderly with and without type 2 diabetes mellitus (DM2), as well as the increased susceptibility to its development. To carry out this cross-sectional study, 5 mL of blood was collected from 45 elderly people. The polymorphism was detected by the multiplex polymerase chain reaction (GSTM1 and GSTT1 polymorphisms). Functional physical aspects were assessed using physical tests. For statistical analysis, the Shapiro-and Qui Square tests ‫)²א(‬ were used. The presence of the GSTM1 and GSTT1 genes were more prevalent. There was a significant association between GSTT1 null genotypes and the presence / absence of DM2. No association was found between genotypes and functional physical aspects. It is concluded that the nullity of the GSTT1 genotype is associated with the susceptibility of DM2, but without a statistically significant relationship with functional physical aspects.

Introdução : A presença de restrições visuais na infância leva a desvios e difi - culdades nas habilidades sensório-motoras. Objetivos : Verificar as respostas do treinamento sensório-motor no equilíbrio e coordenação de crianças com defici - ência visual. Métodos : Trata-se de um relato de casos não controlado, transversal. A amostra foi composta por duas crianças em idade escolar, com diagnóstico oftalmológico de baixa visão e cegueira total. Foram aplicados o Teste de equilí - brio de Berg e o Teste de Coordenação Corporal para Crianças - Bateria de Testes KTK antes e após 10 atendimentos, duração média de 50 minutos, duas vezes na semana. Resultados : Para a Criança 1 observou-se melhora de aproximada - mente 11% para coordenação e 13% no equilíbrio; e para a Criança 2 verificou-se aumento de 17% na coordenação, e 6% para o equilíbrio. Conclusão : O protocolo utilizado trouxe benefícios para o equilíbrio e resposta motora destas crianças com deficiência visual.